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1.
BMC Psychiatry ; 21(1): 547, 2021 11 08.
Article in English | MEDLINE | ID: mdl-34749690

ABSTRACT

BACKGROUND: A key component of caring for service users (SUs) in acute mental health inpatient environments is Therapeutic Engagement (TE). To that end, the Therapeutic Engagement Questionnaire (TEQ) was developed and validated. The TEQ measures TE between SUs and registered mental health nurses (RMHNs) from the perspective of both parties and can quantify and recognise how nurses engage with SUs and monitor this activity as well as its enhancement of SU care and recovery. The aim of this study was to explore the views of SUs and RMHNs in relation to the TEQ and how it could be adopted into clinical practice within an acute inpatient environment. METHODS: As part of the validation stage of the development of the TEQ, the views of 628 SUs and 543 RMHNs were collected using a qualitative approach by way of free text at the end of the questionnaire. Two questions required free text response: - 'what do you think of the TEQ?', and 'how can it be utilised?' RESULTS: Following thematic analysis, it was found that both sets of participants stated that such a tool could be utilised to improve the service, could help nurses with reflective practice, be utilised as part of clinical supervision and to aid nurses' professional development. The nurse participants also stated that such a tool would help track SU participation and enablement in their care. Furthermore, the nurses noted that the tool would help to reinforce the core 'caring' value of nursing and the overall goal of recovery. The SUs added that the TEQ would recognise the work of mental health nurses and provide them with a clear opportunity to express their views in relation to nursing staff. CONCLUSIONS: Therapeutic engagement (TE) has been identified as part of the repertoire of mental health nursing and both groups of participants identified how a tool to assess this construct may be utilised in day-to-day clinical practice to the benefit of each group.


Subject(s)
Mental Health Services , Nurses , Psychiatric Nursing , Humans , Inpatients , Mental Health
2.
Int J Law Psychiatry ; 46: 20-6, 2016.
Article in English | MEDLINE | ID: mdl-27067763

ABSTRACT

Safeguarding, balancing the concept of risk with the need for public protection and its implication for the lives of individuals, is an important facet of contemporary mental health care. Integral to safeguarding is the protection of human rights; the right to live free from torture, inhuman, or degrading treatment, and having the right to liberty, security, respect, and privacy. Professionals are required to recognise all of these rights when delivering care to vulnerable people. In the United Kingdom (UK) there has been growing public concern regarding abusive practices in institutions, with a number of unacceptable methods of restraint being identified as a feature of care, particularly in mental health care. In keeping with the service user movement, and following a review of the literature, this paper discusses the evidence regarding restraint from the perspectives of service users and professionals within mental health services and considers the implications for future practice and research. In reviewing the literature, findings revealed that restraint can be a form of abuse, it's inappropriate use often being a consequence of fear, neglect, and lack of using de-escalation techniques. Using restraint in this way can have negative implications for the well-being of service users and mental health professionals alike.


Subject(s)
Attitude of Health Personnel , Mental Health Services/legislation & jurisprudence , Patient Rights/legislation & jurisprudence , Restraint, Physical/legislation & jurisprudence , Restraint, Physical/psychology , Risk Assessment/legislation & jurisprudence , Adult , Humans , Mental Competency/legislation & jurisprudence , Patient Safety/legislation & jurisprudence , Physical Abuse/legislation & jurisprudence , Physical Abuse/psychology , Politics , Public Opinion , United Kingdom
3.
J Psychiatr Ment Health Nurs ; 22(8): 640-6, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26337595

ABSTRACT

In the Western world, there is increasing concern regarding the ability of health care professionals to meet the physical health care needs of those diagnosed with mental illness. This discussion paper seeks to explore some of the issues facing mental health nurses in delivering care to those who have both mental and physical illness. Criticism of the National Health Service for failing to meet the physical health needs of people with serious mental illness has generated a number of political strategies aimed at addressing inequalities between mental and physical health care, a consequence being a change in pre-registration nurse education. It is envisaged that such changes will enable all nurses to deliver safe, effective care to service users, with adult and mental health nurses being more adept at meeting both the mental and physical health needs of those in their care. The impact of three key areas identified within the literature will be considered: the impact of co-existing physical and mental illness; the role of mental health nurses and perceptions of service users re physical health care; and education, training and learning from others in the Western world. In conclusion, the complexities of delivering such care will be addressed.


Subject(s)
Comorbidity , Health Status , Mental Disorders/therapy , Psychiatric Nursing , Humans , Mental Disorders/epidemiology , Psychiatric Nursing/education , Psychiatric Nursing/methods , Psychiatric Nursing/standards
4.
Nurse Educ Pract ; 11(2): 131-5, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21094090

ABSTRACT

Changes to the pedagogy of pre-registration nurse education and training have become a global phenomenon. However, the evidence base to inform responses to these changes and the impact on nursing practice is limited. This paper explores the outcomes of an innovative approach aimed at ensuring responses to these drivers for change, particularly in curriculum development, the organisation, management and delivery of programmes and the enhancement of the student experience, are evidence based. This paper reports on an organisational change project undertaken in a School of Nursing in the North West of England, UK. The project involved 12 interrelated work streams used to explore aspects of the student journey from recruitment through progression to eventual employment. An evidence base was developed through a methodological bricolage that drew upon a robust and authentic mixture of systematic literature reviews, contemporaneous analysis of educational practice and evaluation of the student experience. This was used to underpin the decision making processes required to promote innovation in programme design, to increase the involvement of students in the facilitation and evaluation of their learning experiences, and helped shape the organisational changes required for embedding an evidenced-based culture in the School. Consistent and transformational leadership has been key to the project's success in communicating and managing the changes.


Subject(s)
Education, Nursing, Baccalaureate/methods , Nursing Education Research/methods , Schools, Nursing/organization & administration , Curriculum/standards , Curriculum/trends , Education, Nursing, Baccalaureate/standards , Education, Nursing, Baccalaureate/trends , England , Evidence-Based Practice , Humans , Nursing Education Research/standards , Organizational Case Studies , Organizational Innovation , Schools, Nursing/trends , Teaching/methods , Teaching/trends
5.
J Psychiatr Ment Health Nurs ; 17(6): 503-9, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20633077

ABSTRACT

Narrative inquiry as a qualitative research method appears to be growing in popularity among mental health nurses. This paper argues that there are a number of parallels between narrative inquiry and psychotherapy, and mental health nurses familiar with the practice of therapeutic engagement need to be mindful of these when using this approach to research. The symbiotic relationship between those engaged in narrative inquiry and those engaged in psychotherapeutic practice is explored in order to provide greater understanding of some of the ethical issues involved and how new researchers, supervisors and practitioners might better respond to the complexities inherent in using narrative inquiry which may itself be therapeutic. Our focus for this paper is the tensions experienced by the mental health nurse while working as a researcher when the research encounter provides a trigger that would normally elicit a therapeutic response for both participant and nurse. Using a selection of psychoanalytic theories and principles this paper explores the relationship between the processes of psychotherapy and narrative inquiry. This discussion paper is based on the authors' own research experiences of using narrative inquiry to explore a number of sensitive issues and many years of supervisory relationships with students and practitioners alike.


Subject(s)
Ethics, Nursing , Mental Disorders/nursing , Narration , Psychiatric Nursing/ethics , Humans , Nurse's Role , Nursing Methodology Research/methods , Psychiatric Nursing/methods
6.
Nurse Educ Today ; 29(8): 855-8, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19450907

ABSTRACT

Drawing upon post doctoral reflections of a shared methodology, the authors explore the use of bricolage as a way of better understanding the inter-related connections between theory, nursing practice and the felt experiences of service users. The origins of bricolage can be traced back to the work of Levi-Strauss, and Denzin and Lincoln's contribution to qualitative methodologies. Bricolage is a multifaceted approach to the research process. Differing epistemological positions and mixed methods of data collection are utilised to bring a richer understanding of human beings and the complexities of their lived experiences. For the bricoleur the object of inquiry, cannot be separated from its context, that is the language used to describe it, its historical situatedness and the social and cultural interpretations of its meaning as an entity in the world. The paper discusses the importance of being able to move beyond the notion of the research method being merely a procedure, to one that respects the complexities of the lived world.


Subject(s)
Education, Nursing , Evidence-Based Nursing , Nurse's Role , Nursing Research , Philosophy, Nursing , Cooperative Behavior , Humans , Models, Nursing , Nursing Methodology Research , Qualitative Research
7.
Int J STD AIDS ; 19(9): 625-8, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18725555

ABSTRACT

In 2004, the management of under-16-year olds in UK genitourinary (GU) medicine clinics was surveyed. Questionnaires were sent to 185 lead GU medicine consultants. A total of 111 questionnaires were returned (60%). Ninety-eight percent of respondents managed young people aged 13-16. Fifty percent managed under 13-year-olds. Twenty-nine percent of respondents ran dedicated young people's clinics. Ninety-eight percent were aware of the National Guidelines, and 74% had adopted them. Fifty-seven percent had a named departmental child protection lead. Thirty-seven percent of consultants had received training specific to child protection issues in GU medicine. Improvements had been made since a similar survey published in 2001, but the need for further training was still apparent.


Subject(s)
Ambulatory Care Facilities/organization & administration , Gynecology/organization & administration , Urology/organization & administration , Adolescent , Child , Female , Gynecology/statistics & numerical data , Health Personnel/education , Health Policy , Health Services Accessibility/organization & administration , Humans , Male , Surveys and Questionnaires , United Kingdom , Urology/statistics & numerical data
8.
J Psychiatr Ment Health Nurs ; 14(2): 155-62, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17352778

ABSTRACT

In the UK, there have been calls to develop gendered specific mental health services for women in an attempt to ensure privacy and dignity are achieved as and when women come into contact with services. This is a largely rhetorical policy objective. There are more fundamental factors affecting women's experience of mental health services that need addressing. This paper explores these issues in the context of mental health care for women who have been 'given' the diagnosis of borderline personality disorder (BPD). Borderline personality disorder effects 2% of the adult population, 75-90% of those diagnosed being women. This diagnosis continues to present considerable conceptual and therapeutic challenges for all of those involved in mental health services and it remains a categorical label that evokes a wide range of conscious and unconscious responses in mental health nurses. The paper argues that mental health nurses need to recognize the defence mechanisms involved in working with individuals who are often difficult to work with. It is only when mental health nurses can embrace and acknowledge the person in the context of their life, that the pejorative and disabling consequences of the BPD label can be eliminated, ensuring the individual's story is heard and not that which is often a pre-constituted account accompanying this diagnosis.


Subject(s)
Attitude of Health Personnel , Borderline Personality Disorder , Nurse-Patient Relations , Prejudice , Psychiatric Nursing/organization & administration , Women/psychology , Adult , Avoidance Learning , Borderline Personality Disorder/diagnosis , Borderline Personality Disorder/psychology , Borderline Personality Disorder/therapy , Child , Child Abuse, Sexual/psychology , Cooperative Behavior , Defense Mechanisms , Female , Health Services Needs and Demand , Humans , Mental Health Services/organization & administration , Negativism , Nurse's Role/psychology , Patient-Centered Care , State Medicine/organization & administration , United Kingdom , Women's Health Services/organization & administration
9.
Nurse Educ Today ; 27(8): 947-54, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17391812

ABSTRACT

The sustained modernisation of the UK primary health care service has resulted in individuals and organisations having to develop more integrated ways of working. This has resulted in changes to the structure and functioning of primary care organisations, changes to the traditional workforce, and an increase in scope of primary care practice. These changes have contributed to what for many staff has become a constantly turbulent organisational and practice environment. Data from a three-year project, commissioned by the North West Development Agency is used to explore how staff involved in these changes dealt with this turbulence. Three hundred and fifty staff working within primary care participated in the study. A multimethods approach was used which facilitated an iterative analysis and data collection process. Thematic analysis revealed a high degree of congruence between the perceptions of all staff groups with evidence of a generally well-articulated, but often rhetorical view of the organisational and professional factors involved in how these changes were experienced. This rhetoric was used by individuals as a way of containing both the good and bad elements of their experience. This paper discusses how these defense mechanisms need to be recognised and understood by managers so that a more supportive organisational culture is developed.


Subject(s)
Attitude of Health Personnel , Cooperative Behavior , Interprofessional Relations , Primary Health Care/organization & administration , Social Work/organization & administration , State Medicine/organization & administration , Adaptation, Psychological , Communication , Community Health Services/organization & administration , Defense Mechanisms , England , Health Care Reform/organization & administration , Health Knowledge, Attitudes, Practice , Health Services Needs and Demand , Humans , Interinstitutional Relations , Leadership , Nursing Methodology Research , Organizational Culture , Organizational Innovation , Professional Role/psychology , Psychoanalytic Interpretation , Surveys and Questionnaires
10.
J Psychiatr Ment Health Nurs ; 13(6): 750-7, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17087679

ABSTRACT

This paper makes a case for the attractiveness of acute mental health inpatient nursing (acute nursing) and argues that an altered perception of this work is essential if we are to provide the most acutely mentally ill and vulnerable people with a stable and expert nursing workforce. The discussion draws on an ethnographic study conducted in an inner-city psychiatric unit in England and the advantages of this method for understanding nursing work are described. Within our findings, we set out two overarching themes: the contextual realities of the contemporary acute ward and features of attraction that encourage nurses to work in the acute care setting. The former includes nurses' responsibility for the total ward environment and the latter the 'comfort of closeness' and 'surviving and thriving in chaos and crisis'. In conclusion, we argue that despite the unpopularity of the acute inpatient mental health environment, the highly sophisticated skills employed by acute nurses actually ensure the promotion of health for the majority of service users.


Subject(s)
Attitude of Health Personnel , Job Satisfaction , Nurse's Role/psychology , Nursing Staff, Hospital/psychology , Psychiatric Nursing , Acute Disease , Adaptation, Psychological , Anthropology, Cultural , Career Choice , Clinical Competence , Empathy , England , Health Facility Environment/organization & administration , Hospital Units/organization & administration , Humans , Interprofessional Relations , Mental Disorders/nursing , Nurse-Patient Relations , Nursing Methodology Research , Nursing Staff, Hospital/organization & administration , Organizational Culture , Psychiatric Nursing/organization & administration , Qualitative Research , Social Support , Surveys and Questionnaires , Workplace/organization & administration , Workplace/psychology
11.
J Psychiatr Ment Health Nurs ; 12(6): 679-86, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16336592

ABSTRACT

The shackles of abuse: unprepared to work at the edges of reason Childhood sexual abuse is an international public health problem. Research suggests similar prevalence rates in both Western and non-Western societies. The long-term consequences of child sexual abuse include wide ranging mental health problems in adult life. Psychiatric services and, in particular, counselling has been highlighted as being the most helpful to those who have experienced child sex abuse. This evidence base should be informing mental health nursing education and practice. However, we argue there is a divergence between the discourse of evidence-based theory and practice reality. The aim of this paper is to explore the preparedness of mental health nurses to work with adults who have experienced sexual abuse during their childhood. It is the first part of a three-part research project and reviews the literature relating to how (and if) mental health nurses are prepared to work with those who have sexual abuse histories. An important issue considered in this review is the impact upon patient/nurse relationships as a consequence of the nurse themselves being survivors of sexual abuse. We argue that a number of conflicting discourses need to be addressed, if mental health nurses are to be appropriately prepared to offer cogent, sensitive care to those in their care who are shackled to their past sexual abuse through the confines of their current mental illness.


Subject(s)
Child Abuse, Sexual/statistics & numerical data , Mental Disorders/epidemiology , Psychiatric Nursing/methods , Adult , Child , Child Abuse, Sexual/psychology , Counseling , Humans , Mental Disorders/therapy , Prevalence
12.
J Psychiatr Ment Health Nurs ; 11(4): 428-34, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15255917

ABSTRACT

International epidemiological studies demonstrate that gay and bisexual males are four times more likely to report a serious suicide attempt than their heterosexual counterparts. Data on completed suicides, usually derived from mortality statistics misrepresent the rate of suicides among homosexual populations. However, an increasing number of studies comparing representative samples of gay, lesbian and bisexual youths with heterosexual controls demonstrate increased rates of mental health problems and subsequent suicide among the homosexual population. Homosexual orientation must therefore be considered a risk factor for mental distress and as such should be a focus for any contemporary public health agenda. One of the difficulties of addressing the problem through a public health agenda is the juxtaposition proffered by our political and social environment. The Diagnostic and Statistical Manual of Mental Disorder ceased to define homosexuality as pathological in 1973 replacing it with a new 'illness' of 'gender identity disorder'. Until recently in England, Section 28 of the Local Government Act (1988), forbidding the promotion of homosexuality, further reinforced negativity towards this group of people. This compounded the negative mental health consequences for those developing a gay sexual orientation in a climate of heterosexism. Current health care policy in England concerns itself with the rising number of suicides among young people but fails to acknowledge the importance of the research findings relating to gay people by integrating them into the development of mental health policy. This paper reviews the literature relating to homosexual people and suicidality, and addresses the seriousness of a policy rhetoric which results from ignoring the evidence while dictating mental health nursing practice.


Subject(s)
Bisexuality/psychology , Homosexuality/psychology , Mental Disorders , Psychiatric Nursing/standards , Suicide Prevention , Suicide/psychology , Female , Homosexuality, Female/psychology , Homosexuality, Male/psychology , Humans , Male , Mental Disorders/diagnosis , Mental Disorders/nursing , Nursing Methodology Research , Risk Factors , Suicide, Attempted/prevention & control , Suicide, Attempted/psychology , United Kingdom
13.
J Psychiatr Ment Health Nurs ; 11(2): 179-84, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15009493

ABSTRACT

The United Kingdom is currently experiencing a recruitment and retention crisis in its nursing workforce. Mental health care is a particular problem area. Widening access to health and social care careers is a challenge for educational and health care organizations. This discussion paper examines the congruence between an educational programme aimed at developing Mental Health Assistant Practitioners' and the organizational responses to the subsequent opportunities for practice innovation within mental health care services. Whilst the 'learning while working' philosophy of the educational programme has been enthusiastically embraced by many health care organizations, the change in management required for using these assistant practitioners in service innovation appears beset by organizational, cultural and professional concerns. Not least of which are the often ambiguous concepts of the role and purpose of being a mental health nurse. This paper argues that if current mental health nurses are unclear about their role it is oxymoronic to establish the mental health assistant practitioners.


Subject(s)
Mental Health Services , Nursing Assistants , Psychiatric Nursing , Humans , Nurse's Role , Organizational Innovation , United Kingdom , Workforce
14.
J Psychiatr Ment Health Nurs ; 10(5): 616-21, 2003 Oct.
Article in English | MEDLINE | ID: mdl-12956641

ABSTRACT

This paper explores the first issues encountered when establishing a method of service user involvement in the preparation of a cohort of mental health nursing students during their branch programme. The method involved the creation of a group of service users and students whose purpose was to jointly reflect upon mental health issues. To do this students are expected to use their experience from practice placements and the service users to use their experiences as recipients of mental health services. This approach is being investigated through research utilizing an evaluative case study with features of action research incorporated into the design. The findings to date, which concern the process of negotiation, pre-study attitudinal survey and the first group process, will be presented. This will offer mental health professionals the opportunity to gain insight into one approach of actively involving service users in programmes of higher education over a sustained period of time. Reflection on practice themes will include: collaborative strategy, evaluative case study, education, mental health nursing, reflection on practice, and service-user involvement.


Subject(s)
Education, Nursing/organization & administration , Mental Health Services , Psychiatric Nursing/education , Humans
15.
16.
AAOHN J ; 48(1): 32-45; quiz 46-7, 2000 Jan.
Article in English | MEDLINE | ID: mdl-15635918

ABSTRACT

Substance abuse continues to impact the workplace. Impaired employees impact the safety of themselves, fellow employees, the public, and the physical plant. Occupational and environmental health care providers must be familiar with the seven psychoactive drug categories. In addition, they must consider other causes for behavior, such as medical, psychological, toxicological, or strictly performance issues. A standardized process should be developed and used when providing work fitness impairment evaluations.


Subject(s)
Nurse's Role , Occupational Health Nursing/organization & administration , Substance-Related Disorders , Workplace , Humans , Nursing Assessment , Occupational Health Services/organization & administration , Organizational Policy , Patient Care Planning , Physical Examination , Physical Fitness , Practice Guidelines as Topic , Safety Management/organization & administration , Substance Abuse Detection , Substance-Related Disorders/diagnosis , Substance-Related Disorders/etiology , Substance-Related Disorders/therapy , Workplace/organization & administration
18.
J Biol Chem ; 270(34): 19839-44, 1995 Aug 25.
Article in English | MEDLINE | ID: mdl-7649995

ABSTRACT

A 15-mer phage display random peptide library was screened with purified bovine Hsc70, and nucleotide sequence analysis of the selected clones showed a large enrichment for peptides containing basic sequences with at least KK, KR, or RR. Binding affinity for Hsc70 of representative peptides increased dramatically for heptamers compared with hexamers. The peptide NIVRKKK had the highest affinity for Hsc70, and substitution analyses showed that hydrophobic residues followed by basic residues play important roles in maintaining this affinity. In contrast, NIVRKKK was a weaker stimulator of the Hsc70 ATPase activity compared with pigeon cytochrome c peptide and FYQLALT, a peptide optimized for binding to Hsc70. FYQLALT effectively blocked the binding of NIVRKKK to Hsc70, possibly by causing a conformational change that masked Hsc70's binding site for the basic peptide. Two hypotheses are offered to explain the two different peptide motifs. First, it is proposed that Hsc70 recognizes two different amino acid sequence motifs in its dual roles of chaperoning proteins to organelles (NIVRKKK-like sequences) and facilitating protein folding (FYQLALT-like sequences). Second, the NIVRKKK motif may be used to bind certain folded proteins with which Hsc70 interacts, such as itself, p53, and Dnaj2.


Subject(s)
Carrier Proteins/genetics , Carrier Proteins/metabolism , HSP70 Heat-Shock Proteins , Oligopeptides/genetics , Oligopeptides/metabolism , Peptides/genetics , Peptides/metabolism , Amino Acid Sequence , Animals , Binding Sites , Binding, Competitive , Cattle , Cytochrome c Group/genetics , Gene Library , HSC70 Heat-Shock Proteins , In Vitro Techniques , Inovirus/genetics , Molecular Sequence Data , Organelles/metabolism , Protein Binding , Protein Conformation , Protein Folding
20.
Cancer Res ; 53(2): 334-9, 1993 Jan 15.
Article in English | MEDLINE | ID: mdl-8417827

ABSTRACT

We have constructed a single-chain immunotoxin composed of the carcinoma-reactive antibody BR96 and a truncated form of Pseudomonas exotoxin. The chimeric molecule, BR96 sFv-PE40, was expressed in Escherichia coli and localized to the inclusion bodies. We purified and identified two species of BR96 sFv-PE40, monomers and aggregates. The monomeric form was able to bind well to the BR96 antigen, a Lewisy-related antigen, while the aggregate was not. The binding affinity of the monomeric recombinant immunotoxin was 5-fold less than intact BR96 IgG, and its specificity for the BR96 antigen was confirmed by competition analysis. Monomeric BR96 sFv-PE40 was found to be extremely cytotoxic against cancer cells displaying the BR96 antigen. The cytotoxicity of the fusion protein correlates directly with antigen density on the tumor cell lines tested. The breast carcinoma cell line MCF-7, which has the highest density of BR96 antigen, was the most sensitive to BR96 sFv-PE40, with a concentration producing 50% protein synthesis inhibition of 5 pM. BR96 sFv-PE40 was found to have a t1/2 in serum of 28.5 min in athymic mice, compared to that of the chemical conjugate, chiBR96-LysPE40, which was 54 min. These data indicate that the single-chain immunotoxin BR96 sFv-PE40 is a potent inhibitor of protein synthesis in target cell lines and may be an effective agent for the treatment of cancer.


Subject(s)
ADP Ribose Transferases , Bacterial Toxins , Immunotoxins , Recombinant Fusion Proteins , Virulence Factors , Antibodies, Neoplasm/chemistry , Antigens, Tumor-Associated, Carbohydrate/immunology , Base Sequence , Breast Neoplasms/immunology , Breast Neoplasms/therapy , Carcinoma/immunology , Carcinoma/therapy , Cloning, Molecular , Exotoxins/chemistry , Humans , Immunotoxins/metabolism , In Vitro Techniques , Lewis Blood Group Antigens/immunology , Metabolic Clearance Rate , Molecular Sequence Data , Oligonucleotides/chemistry , Recombinant Fusion Proteins/metabolism , Tumor Cells, Cultured , Pseudomonas aeruginosa Exotoxin A
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