1.
Angew Chem Int Ed Engl
; 51(4): 1006-9, 2012 Jan 23.
Article
in English
| MEDLINE
| ID: mdl-22162111
2.
Org Lett
; 13(14): 3667-9, 2011 Jul 15.
Article
in English
| MEDLINE
| ID: mdl-21671610
ABSTRACT
A new approach to the Fischer-indole synthesis is reported that uses the reactive intermediate benzyne. The addition of N-tosyl hydrazones to arynes, generated through fluoride activation of 2-(trimethylsilyl)phenyl triflate precursors, leads to efficient N-arylation. Addition of a Lewis acid to the same reaction pot then affords N-tosylindole products via Fischer cyclization.