ABSTRACT
Panasonic UD-801 thermoluminescent dosimeters ( TLDs ) containing two calcium sulfate phosphors were tested under Performance Specification 3.1 established by the American National Standard Institute ( ANSI75 ) and in the U.S. Nuclear Regulatory Commission's Regulatory Guide 4.13 ( NRC77 ). The specific qualifying tests included TLD uniformity, reproducibility, energy dependence and directional dependence. The overall measurement uncertainties and associated confidence levels are within the prescribed guidelines defined in the qualifying requirements for environmental TLDs .
Subject(s)
Accidents , Nuclear Reactors , Radioactive Pollutants/analysis , Thermoluminescent Dosimetry/standards , PennsylvaniaABSTRACT
The deterioration of stannous ion (Sn++) in inhouse-prepared and commercial radiopharmaceutical kits was studied. Sn++ content of three types of nonlyophilized, deoxygenated, aqueous inhouse-prepared kits [diethylenetriamine pentaacetic acid (DTPA), pyrophosphate and glucoheptonate] and of three commercially prepared kits (two lyophilized pyrophosphate kits and one diphosphonate in sealed glass ampul kit) was measured by differential pulse polarography. Inhouse-prepared kits were assayed initially and after storage for 6, 12, 24 and 48 days at 24, 5 and -18 C. Commercial kits were assayed initially and after storage for 12, 24 and 48 days at 5 and 24 C. Of the inhouse-prepared kits, Sn++ stability when stored for 48 days at 5 and 24 C. Freezer storage should be used, when possible, to insure maximum stability of Sn++ in inhouse-prepared, nonlyophilized ratiopharmaceutical kits. The commercial procedures of lyophilization and of sealing the reagent in a sealed glass ampul prolong Sn++ stability.
Subject(s)
Tin/analysis , Drug Stability , Drug Storage , Nuclear Medicine , Reagent Kits, DiagnosticSubject(s)
Adrenal Glands/growth & development , Neurophysiology , Adrenal Glands/drug effects , Adrenal Glands/innervation , Adrenalectomy , Adrenocorticotropic Hormone/pharmacology , Afferent Pathways , Animals , Dexamethasone/pharmacology , Efferent Pathways , Hypophysectomy , Hypothalamo-Hypophyseal System/innervation , Hypothalamus/physiology , Male , Pituitary Gland/physiology , Pituitary-Adrenal System/innervation , RatsABSTRACT
Stannous salts are used as reducing agents in many radiopharmaceutical kits. Differential pulse polarography, with 1 M sulfuric acid as the supporting electrolyte, is a relatively simple and effective technique for stannous quantitation and can be used in the quality assurance testing of pyrophosphate and polyphosphate radiopharmaceutical kits.
