Subject(s)
Blood Proteins/metabolism , Dronabinol/blood , Animals , Binding, Competitive , Male , Protein Binding , RatsABSTRACT
Isotope effect studies on the metabolic dehydrogenation of delta 1-tetrahydrocannabinol in rats are described and it is shown that this process is confined to a very short period following i.v. administration. The implications of this finding are discussed.
Subject(s)
Cannabinoids/blood , Cannabinol/blood , Dronabinol/blood , Animals , Carbon Radioisotopes , Rats , TritiumABSTRACT
Co-administration of cannabidiol with delta1-tetrahydrocannabinol was found to have no effect on the rate of disappearance of delta1-tetrahydrocannabinol from the blood of rats. The implications of this finding are discussed.
Subject(s)
Cannabidiol/pharmacology , Cannabis/metabolism , Cannabis/pharmacology , Dronabinol/metabolism , Animals , Cannabidiol/blood , Cannabidiol/metabolism , Dronabinol/blood , Dronabinol/pharmacology , Drug Interactions , Kinetics , Male , RatsABSTRACT
The co-administration of cannabinol with delta1-tetrahydrocannabinol accelerates the rate of clearance of delta1-tetrahydrocannabinol from rat blood. This increased rate of clearance appears to follow that of cannabinol. The implications of these findings are discussed.
