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1.
Broad institute: bringing genomics to real-world medicine.
McCarthy, Alice A.
Chem Biol ; 12(7): 717-8, 2005 Jul.
Article in English | MEDLINE | ID: mdl-16039517

Subject(s)
Academies and Institutes , Genomics , Medicine , Biotechnology , Humans , Medical Informatics Applications , Medicine/organization & administration
2.
Advanced cell technology: embryonic-stem-cell-based regenerative medicine.
McCarthy, Alice A.
Chem Biol ; 12(6): 605-7, 2005 Jun.
Article in English | MEDLINE | ID: mdl-15975502

Subject(s)
Cell- and Tissue-Based Therapy/methods , Regenerative Medicine/methods , Stem Cells/cytology , Stem Cells/metabolism , Animals , Cell- and Tissue-Based Therapy/trends , Histocompatibility , Humans , Regenerative Medicine/trends , Stem Cells/immunology
3.
Dendritic NanoTechnologies, Inc.
McCarthy, Alice A.
Chem Biol ; 12(5): 499-501, 2005 May.
Article in English | MEDLINE | ID: mdl-15911366

Subject(s)
Nanostructures , Nanotechnology/trends , Polymers
4.
Exelixis: integrated drug-discovery and development platform for human therapeutics.
McCarthy, Alice A.
Chem Biol ; 12(4): 407-8, 2005 Apr.
Article in English | MEDLINE | ID: mdl-15850973

Subject(s)
Drug Industry/trends , Antineoplastic Agents/pharmacology , Databases, Genetic , Drug Evaluation, Preclinical , Drug Therapy , Phosphotransferases/antagonists & inhibitors , Receptors, Cell Surface/drug effects , Receptors, Cell Surface/genetics , Software
5.
Inhibitex, Inc: antibody anti-infectives.
McCarthy, Alice A.
Chem Biol ; 12(3): 257-9, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15797206

Subject(s)
Anti-Infective Agents/administration & dosage , Antibodies/administration & dosage , Drug Industry/methods , Membrane Proteins/immunology , Anti-Infective Agents/therapeutic use , Antibodies/therapeutic use , Bacterial Adhesion/immunology , Drug Delivery Systems/methods , Drug Delivery Systems/trends , Drug Industry/trends , Drug Resistance, Microbial
6.
Biolex, Inc.: pharmaceutical production in plants.
McCarthy, Alice A.
Chem Biol ; 12(2): 141-2, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15734639

Subject(s)
Biolistics , Pharmaceutical Preparations , Plants/genetics , Plants, Genetically Modified
7.
New approaches to diabetes disease control, insulin delivery, and monitoring.
McCarthy, Alice A.
Chem Biol ; 11(12): 1597-8, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15610839

Subject(s)
Albuminuria/diagnosis , Diabetes Mellitus, Type 1/therapy , Diabetes Mellitus, Type 2/therapy , Drug Delivery Systems , Insulin/administration & dosage , Albuminuria/complications , Albuminuria/urine , CD3 Complex/immunology , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/prevention & control , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/prevention & control , Humans , Muromonab-CD3/therapeutic use
8.
The genetics of autism.
McCarthy, Alice A.
Chem Biol ; 11(10): 1325-6, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15489156

Subject(s)
Autistic Disorder/genetics , Genetic Predisposition to Disease , Autistic Disorder/diagnosis , Autistic Disorder/physiopathology , Child , Humans
9.
When enough is too much: new strategies to treat obesity.
McCarthy, Alice A.
Chem Biol ; 11(8): 1025-6, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15324799

Subject(s)
Estrone/analogs & derivatives , Obesity/therapy , Drug Industry , Estrone/blood , Estrone/metabolism , Humans , Obesity/blood , Obesity/metabolism , Obesity/prevention & control , Oleic Acids/blood , Oleic Acids/metabolism , Peptide Fragments , Peptide YY/administration & dosage , Peptide YY/blood , Peptide YY/pharmacokinetics , Satiety Response/physiology , United States
10.
Polymerix corporation: polymer drugs for device and injection.
McCarthy, Alice A.
Chem Biol ; 11(7): 885-6, 2004 Jul.
Article in English | MEDLINE | ID: mdl-15271342

Subject(s)
Chemical Industry , Drug Carriers , Polymers/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Delayed-Action Preparations
11.
Elixir Pharmaceuticals: targeting molecular sources of aging.
McCarthy, Alice A.
Chem Biol ; 11(6): 733-4, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15217602

Subject(s)
Aging/genetics , Aging/metabolism , Drug Industry , Animals , Caenorhabditis elegans Proteins , Carrier Proteins/metabolism , Drug Design , Drug Industry/trends , Humans , Lamin Type A/genetics , Lamin Type A/metabolism , Male , Receptor, IGF Type 1/metabolism , Receptor, Insulin/metabolism , Sirtuins/metabolism
12.
Hydra Biosciences: inducing nature's regenerative power.
McCarthy, Alice A.
Chem Biol ; 11(5): 585-6, 2004 May.
Article in English | MEDLINE | ID: mdl-15157867

Subject(s)
Biotechnology/trends , Myocytes, Cardiac/cytology , Regenerative Medicine/trends , Animals , Cell Proliferation , Endothelium, Vascular/cytology , Endothelium, Vascular/metabolism , Growth Substances/physiology , Mice , Rats
13.
Xanthus Life Sciences. Fine-tuning personalized medicine.
McCarthy, Alice A.
Chem Biol ; 10(8): 673-4, 2003 Aug.
Article in English | MEDLINE | ID: mdl-12954325

Subject(s)
Antineoplastic Agents/therapeutic use , Biomedical Research , Drug Industry , Neoplasms/drug therapy , Research Support as Topic , Biomedical Research/economics , Drug Industry/economics , Humans
14.
Theravance. Medicines that make a difference.
McCarthy, Alice A.
Chem Biol ; 10(6): 473-4, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12837376

Subject(s)
Drug Design , Technology, Pharmaceutical/trends , Adrenergic beta-Agonists/chemical synthesis , Anti-Bacterial Agents/chemical synthesis , Bronchodilator Agents/chemical synthesis , Cholinergic Antagonists/chemical synthesis , Drug Delivery Systems , Humans , Technology, Pharmaceutical/organization & administration , United States
15.
Infinity Pharmaceuticals. Back to the future.
McCarthy, Alice A.
Chem Biol ; 10(4): 293-4, 2003 Apr.
Article in English | MEDLINE | ID: mdl-12725855

Subject(s)
Drug Design , Drug Industry/trends , Chemical Phenomena , Chemistry , Computational Biology , Databases as Topic , Drug Evaluation, Preclinical , Molecular Biology
16.
Microbia: engineering microbial network biology.
McCarthy, Alice A.
Chem Biol ; 10(2): 99-100, 2003 Feb.
Article in English | MEDLINE | ID: mdl-12618178

Subject(s)
Bacteria/metabolism , Biotechnology/trends , Fungi/metabolism , Protein Engineering , Adhesins, Bacterial/metabolism , Drug Industry
17.
Metaphore Pharmaceuticals: mimicking nature's enzyme.
McCarthy, Alice A.
Chem Biol ; 10(12): 1139-40, 2003 Dec.
Article in English | MEDLINE | ID: mdl-14700617

Subject(s)
Drug Design , Drug Industry , Molecular Mimicry , Superoxide Dismutase/metabolism , Humans , Inflammation/drug therapy , Inflammation/enzymology , Pain/drug therapy , Pain/enzymology , Superoxides/metabolism
18.
Basilea pharmaceutica AG mining a rich inheritance.
McCarthy, Alice A.
Chem Biol ; 9(12): 1257-8, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12498874

Subject(s)
Drug Industry/organization & administration , Anti-Infective Agents , Combinatorial Chemistry Techniques , Dermatologic Agents , Drug Industry/methods , Research
19.
Genta incorporated. Gallium therapeutics: take two.
McCarthy, Alice A.
Chem Biol ; 9(10): 1051-2, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12401488

Subject(s)
Antineoplastic Agents/therapeutic use , Gallium/therapeutic use , Neoplasms/drug therapy , Antineoplastic Agents/adverse effects , Antineoplastic Agents/chemistry , Antineoplastic Agents/metabolism , Chemistry, Pharmaceutical , Clinical Trials, Phase II as Topic , Gallium/adverse effects , Gallium/chemistry , Gallium/metabolism , Humans
20.
Kosan biosciences. Better chemistry through genetics.
McCarthy, Alice A.
Chem Biol ; 9(8): 849-50, 2002 Aug.
Article in English | MEDLINE | ID: mdl-12204680

Subject(s)
Drug Industry/methods , Biotechnology/methods , Epothilones/biosynthesis , Epothilones/chemical synthesis , Fermentation , Gene Transfer Techniques , Multienzyme Complexes/genetics
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