Unmet and Exceeded Expectations for Sexual Concerns across the Transition to Parenthood.

Expectations play a key role in shaping sexual and relationship well-being. Across the transition to parenthood, couples navigate many changes to their sexual relationships, yet little is known about their expectations related to sex. This longitudinal study investigated how unmet and exceeded expectations for postpartum sexual concerns - assessed in pregnancy and compared to experiences at 3-months postpartum - affect sexual and relationship well-being. Data were collected from 200 new-parent couples mid-pregnancy and at 3, 6, 9, and 12-months postpartum. Mothers' unmet expectations (i.e., sexual experiences were worse than expected) were associated with their own lower sexual and relationship satisfaction at 3-months postpartum. Partners' unmet expectations were associated with their own lower sexual satisfaction, higher sexual distress and relationship conflict, and mothers' lower sexual satisfaction. Mothers' exceeded expectations (i.e., sexual experiences were not as bad as they expected) were linked to their own and their partners' higher sexual satisfaction and lower sexual distress and relationship conflict at 3-months postpartum. Partners' exceeded expectations were only associated with mothers' lower sexual distress at 3-months postpartum. Expectations did not predict change in outcomes over time. Findings provide novel evidence that expectations for one's sexual relationship are associated with new parents' sexual and relationship adjustment during a vulnerable period for sexuality and well-being.

Simultaneous monitoring of potassium, glucose and lactate during spreading depolarization in the injured human brain - Proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis.

Spreading depolarizations occur spontaneously and frequently in injured human brain. They propagate slowly through injured tissue often cycling around a local area of damage. Tissue recovery after an spreading depolarization requires greatly augmented energy utilisation to normalise ionic gradients from a virtually complete loss of membrane potential. In the injured brain, this is difficult because local blood flow is often low and unreactive. In this study, we use a new variant of microdialysis, continuous on-line microdialysis, to observe the effects of spreading depolarizations on brain metabolism. The neurochemical changes are dynamic and take place on the timescale of the passage of an spreading depolarization past the microdialysis probe. Dialysate potassium levels provide an ionic correlate of cellular depolarization and show a clear transient increase. Dialysate glucose levels reflect a balance between local tissue glucose supply and utilisation. These show a clear transient decrease of variable magnitude and duration. Dialysate lactate levels indicate non-oxidative metabolism of glucose and show a transient increase. Preliminary data suggest that the transient changes recover more slowly after the passage of a sequence of multiple spreading depolarizations giving rise to a decrease in basal dialysate glucose and an increase in basal dialysate potassium and lactate levels.