Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 12 de 12
Filter
Add more filters









Publication year range
1.
Ultrastructural study of selenite-induced nuclear cataracts.
Russell, N J; Royland, J E; McCawley, E L; Shearer, T R.
Invest Ophthalmol Vis Sci ; 25(6): 751-7, 1984 Jun.
Article in English | MEDLINE | ID: mdl-6724845

ABSTRACT

The formation of the selenite-induced cataract was investigated by examining the ultrastructure of the cataract with transmission electron microscopy (TEM). A lacy, or honeycomb, appearance of the nuclear cataract seen by light microscopy was resolved by TEM to be due to the aggregation or precipitation of cytoplasmic material. Despite severe intracellular changes the fibers retained their close apposition to one another. These results are consistent with the hypothesis that a major lesion in selenite-induced nuclear cataracts is the formation of insoluble cytoplasmic aggregates.


Subject(s)
Cataract/pathology , Animals , Cataract/chemically induced , Microscopy, Electron , Rats , Selenious Acid , Selenium/adverse effects
2.
Melanosis coli in the guinea pig: a light and electron microscopic study.
Russell, N J; Royland, J E; McCawley, E L.
Proc West Pharmacol Soc ; 25: 193-5, 1982.
Article in English | MEDLINE | ID: mdl-7122493

Subject(s)
Colon/pathology , Melanosis/pathology , Animals , Cecum/pathology , Guinea Pigs , Ileum/pathology , Microscopy, Electron
3.
Prevention by propranolol of ouabain cardiotoxicity: physiological, biochemical and ultrastructural correlations.
Tanz, R D; Russell, N J; McCawley, E L.
Proc West Pharmacol Soc ; 25: 51-3, 1982.
Article in English | MEDLINE | ID: mdl-7122539

Subject(s)
Heart Diseases/chemically induced , Ouabain/toxicity , Propranolol/pharmacology , Animals , Coronary Circulation/drug effects , Guinea Pigs , Heart Diseases/metabolism , Heart Diseases/physiopathology , Myocardium/metabolism , Oxygen Consumption/drug effects
4.
Danthron induced melanosis coli in the guinea pig.
Russell, N J; Royland, J E; McCawley, E L.
Proc West Pharmacol Soc ; 23: 277-80, 1980.
Article in English | MEDLINE | ID: mdl-7403144

Subject(s)
Anthraquinones/toxicity , Cathartics/toxicity , Colonic Diseases/chemically induced , Melanosis/chemically induced , Animals , Cecum/pathology , Colon/pathology , Colonic Diseases/pathology , Female , Guinea Pigs , Ileum/pathology , Male , Melanosis/pathology , Time Factors
5.
Antagonism of metrazol-induced convulsions by sodium bromide in Rana pipiens.
Johnson, S W; McCawley, E L; Riker, W K.
Proc West Pharmacol Soc ; 20: 57-62, 1977.
Article in English | MEDLINE | ID: mdl-302452

Subject(s)
Bromides/pharmacology , Pentylenetetrazole/antagonists & inhibitors , Seizures/physiopathology , Animals , Anura , Bromides/administration & dosage , Dose-Response Relationship, Drug , Rana pipiens , Seizures/chemically induced
6.
Measurement of variation of drug responses: sequential analysis of quantal sensitivity data.
McCawley, E L; Wayson, K A.
Physiol Chem Phys ; 6(3): 275-82, 1974.
Article in English | MEDLINE | ID: mdl-4500016

Subject(s)
Drug Therapy/methods , Research Design , Animals , Humans , Mathematics , Mice , Models, Biological , Pentanes/toxicity , Procaine/toxicity
7.
The significance of advisory-review committees during clinical investigations of drugs.
McCawley, E L; Hart, H C; Crowe, A W.
Clin Pharmacol Ther ; 13(3): 299-306, 1972.
Article in English | MEDLINE | ID: mdl-5026370

Subject(s)
Peer Review , Drug and Narcotic Control , Humans , Informed Consent , Methadone/therapeutic use , Substance-Related Disorders , Utilization Review
8.
Effect of ultrasound on the canine mitral valve.
Reeves, M M; Dick, L H; McCawley, E L.
Med Res Eng ; 8(2): 16-7 passim, 1969.
Article in English | MEDLINE | ID: mdl-5778873

Subject(s)
Heart Valve Diseases/etiology , Mitral Valve/pathology , Ultrasonics/adverse effects , Animals , Dogs , Heart Failure/etiology , Heart Valve Diseases/pathology , Rheumatic Heart Disease/etiology
9.
Effect of quinidine on the isotopic homotransplanted heart: a preliminary report.
Reeves, M M; McCawley, E L; Dick, H L.
Proc West Pharmacol Soc ; 10: 80-3, 1967.
Article in English | MEDLINE | ID: mdl-4861638

Subject(s)
Heart Transplantation , Heart/drug effects , Quinidine/pharmacology , Animals , Dogs , Electrocardiography , Models, Biological , Transplantation, Homologous
10.
Anesthesia with cyclic hydrocarbons.
Winters, R H; McCawley, E L.
Proc West Pharmacol Soc ; 10: 70-3, 1967.
Article in English | MEDLINE | ID: mdl-4964241

Subject(s)
Anesthesia, Inhalation , Spiro Compounds/pharmacology , Animals , Arrhythmias, Cardiac/chemically induced , Cyclopentanes/pharmacology , Cyclopropanes/pharmacology , Dogs , Epinephrine/pharmacology , Ethyl Ethers/pharmacology , Halothane/pharmacology , Haplorhini , Male , Mice
11.
Quinidine-induced tachycardia in dogs with bundle branch block.
McCawley, E L; Dick, L H; Reeves, M M; Urbanc, A N.
J Pharmacol Exp Ther ; 153(3): 515-22, 1966 Sep.
Article in English | MEDLINE | ID: mdl-5922324

Subject(s)
Bundle-Branch Block/drug therapy , Bundle-Branch Block/physiopathology , Quinidine/adverse effects , Tachycardia/chemically induced , Animals , Dogs , Electrocardiography
12.
Studies with quinidine and digoxin on the cardiac vulnerable period.
McCawley, E L; Dick, H L; Reeves, M.
Proc West Pharmacol Soc ; 9: 9-12, 1966.
Article in English | MEDLINE | ID: mdl-5958505

Subject(s)
Arrhythmias, Cardiac/prevention & control , Digoxin/therapeutic use , Quinidine/therapeutic use , Tachycardia/prevention & control , Ventricular Fibrillation/prevention & control , Animals , Dogs , Electric Countershock , Electric Stimulation , Electrocardiography , Electrophysiology , Heart Block/chemically induced , Heart Conduction System/drug effects
SEND TO:
Email
Export
Print
RSS
XML
SELECTION OF CITATIONS
SEARCH DETAIL