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Curr Hematol Malig Rep ; 6(3): 195-205, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21695425

ABSTRACT

As survival rates for children treated for childhood cancers become significantly better, the focus is increasingly on determining the late effects of treatments and the best ways to monitor for them and prevent their occurrence. This review focuses on recent literature discussing the late effects of treatment in patients treated for acute myeloid leukemia and acute lymphoblastic leukemia during childhood. The late effects of therapy for childhood leukemia include secondary malignancy, cardiotoxicity, obesity, endocrine abnormalities, reproductive changes, neurocognitive deficits, and psychosocial effects. As clinicians have become more aware of the late effects of therapy, treatment regimens have been changed to decrease late effects, but patients still require long-term follow-up for their prevention and treatment.


Subject(s)
Leukemia, Myeloid, Acute/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Antineoplastic Agents/adverse effects , Antineoplastic Agents/pharmacology , Antineoplastic Agents/therapeutic use , Central Nervous System Neoplasms/secondary , Child , Endocrine System Diseases/chemically induced , Endocrine System Diseases/etiology , Fertility/drug effects , Growth Disorders/chemically induced , Growth Disorders/etiology , Heart Diseases/chemically induced , Heart Diseases/etiology , Humans , Leukemia, Myeloid, Acute/pathology , Obesity/chemically induced , Obesity/etiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology , Stress, Psychological
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