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5.
Biochem J ; 138(2): 317-20, 1974 Feb.
Article in English | MEDLINE | ID: mdl-4362746

ABSTRACT

A method is described for isolating cyclic [(3)H]GMP from platelets preincubated with [(3)H]guanine. Collagen increased and aspirin decreased the cyclic [(3)H]GMP concentration in platelets. The results are consistent with a role for cyclic GMP in the platelet release reaction.


Subject(s)
Aspirin/pharmacology , Blood Platelets/metabolism , Collagen/pharmacology , Cyclic GMP/blood , Blood Platelets/drug effects , Chromatography, Thin Layer , Guanine/metabolism , Humans , In Vitro Techniques , Platelet Adhesiveness , Time Factors , Tritium
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