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J Clin Microbiol ; 43(2): 973-7, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15695722

ABSTRACT

An immunocompromised patient with an invasive soft tissue infection due to Scedosporium apiospermum was successfully treated with voriconazole and surgical debridement. After transition from intravenous to oral therapy, successive adjustments of the oral dose were required to achieve complete resolution. For soft tissue infections due to molds characterized by thin, septate hyphae branching at acute angles, voriconazole should be considered a first-line antifungal agent. The potential usefulness of plasma voriconazole levels for guiding optimal therapy should be investigated.


Subject(s)
Antifungal Agents/administration & dosage , Mycetoma/drug therapy , Pyrimidines/administration & dosage , Scedosporium/drug effects , Soft Tissue Infections/drug therapy , Triazoles/administration & dosage , Administration, Oral , Antifungal Agents/therapeutic use , Arm/pathology , Female , Hand/pathology , Humans , Injections, Intravenous , Microbial Sensitivity Tests , Middle Aged , Mycetoma/microbiology , Mycetoma/pathology , Mycetoma/surgery , Pyrimidines/therapeutic use , Soft Tissue Infections/pathology , Soft Tissue Infections/surgery , Treatment Outcome , Triazoles/therapeutic use , Voriconazole
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