ABSTRACT
Two cases that involve drug compounding errors are described. One dog exhibited increased seizure activity due to a compounded, flavored phenobarbital solution that deteriorated before the expiration date provided by the compounder. The other dog developed clinical signs of hyperkalemia and bromine toxicity following a 5-fold compounding error in the concentration of potassium bromide (KBr).
Subject(s)
Anticonvulsants/adverse effects , Dog Diseases/chemically induced , Drug Compounding/veterinary , Medication Errors/veterinary , Seizures/veterinary , Animals , Anticonvulsants/therapeutic use , Bromides/blood , Bromides/therapeutic use , Dog Diseases/blood , Dog Diseases/drug therapy , Dogs , Drug Compounding/adverse effects , Male , Phenobarbital/adverse effects , Phenobarbital/therapeutic use , Potassium Compounds/blood , Potassium Compounds/therapeutic use , Seizures/drug therapyABSTRACT
A 1.5-year-old dog was evaluated for abnormal mentation, collapse, and weight loss. Radiographs and ultrasonographs revealed soft tissue masses in the mid abdomen. Ultrasound-guided fine-needle aspirates provided a diagnosis of malignant epithelial or round cell neoplasia. Histopathologic and immunohistochemical findings on the tumors were consistent with a primitive neuroblastoma.
Subject(s)
Adrenal Gland Neoplasms/veterinary , Dog Diseases/pathology , Neuroblastoma/veterinary , Adrenal Gland Neoplasms/diagnostic imaging , Adrenal Gland Neoplasms/pathology , Animals , Biopsy, Fine-Needle/veterinary , Dog Diseases/diagnostic imaging , Dogs , Fatal Outcome , Female , Neuroblastoma/diagnostic imaging , Neuroblastoma/pathology , Radiography , Ultrasonography , Weight LossABSTRACT
A dog adopted as a stray in Spain and then brought to Canada 4 years prior to presentation was evaluated for polyarthritis. An electrophoresis showed a marked polyclonal gammopathy and synovial smears contained leishmanial organisms within macrophages.
