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1.
Genes Immun ; 3(7): 433-5, 2002 Nov.
Article in English | MEDLINE | ID: mdl-12424627

ABSTRACT

A recent study employing Australian and UK type 1 diabetes families has demonstrated significant transmission bias to affected offspring of a polymorphism (1188A allele; termed allele 1) in the 3' untranslated region (3'UTR) of the interleukin 12B (IL12B) gene which encodes the IL-12p40 subunit of the pro-inflammatory cytokine IL-12. However, results from replication studies in other populations have been controversial. We performed both case-control (n=120 cases; n=330 controls) and family-based (n=307 families) association studies, using the transmission disequilibrium test, to investigate if allele 1 is associated with early-onset type 1 diabetes in Northern Ireland. No association was observed between allele 1 and type 1 diabetes in either case-control (80.8% vs 80.8%; P=0.98) or family-based (49.7% transmissions; P=0.94) studies. Our results do not support earlier reports of an association between allele 1 in the 3'UTR of the IL12B gene and type 1 diabetes.


Subject(s)
3' Untranslated Regions , Diabetes Mellitus, Type 1/genetics , Interleukin-12/genetics , Polymorphism, Genetic , Adolescent , Age of Onset , Case-Control Studies , Child , Diabetes Mellitus, Type 1/epidemiology , Female , Genetic Predisposition to Disease , Humans , Male
2.
Genes Immun ; 2(4): 233-5, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11477480

ABSTRACT

Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.


Subject(s)
Antigens, Differentiation/genetics , DNA/genetics , Diabetes Mellitus, Type 1/genetics , Immunoconjugates , Polymorphism, Genetic , Abatacept , Antigens, CD , CTLA-4 Antigen , Case-Control Studies , Diabetes Mellitus, Type 1/ethnology , Humans , Northern Ireland
4.
J Hand Surg Am ; 5(6): 568-71, 1980 Nov.
Article in English | MEDLINE | ID: mdl-7000884

ABSTRACT

Accidental, excessive exposure to therapeutic radiation of the hands is rare and some authors advocate early amputation of the part. A report of the treatment of excessive irradiation to both hands for verrucous lesions in an 18-year-old woman includes a 21 year follow-up without evidence of malignant degeneration.


Subject(s)
Hand Injuries/surgery , Radiation Injuries/surgery , Radiotherapy/adverse effects , Adolescent , Female , Follow-Up Studies , Hand Dermatoses/radiotherapy , Humans , Skin Transplantation , Surgical Flaps , Transplantation, Autologous , Warts/radiotherapy
6.
Clin Plast Surg ; 3(1): 77-83, 1976 Jan.
Article in English | MEDLINE | ID: mdl-765051

ABSTRACT

The treatment of burnt hands is not simple. By emphasizing problems that are frequently encountered, I have attempted to stress certain methods of treatment based on sound principles of burn wound care and skin grafting. Great responsibility rests on the person who does the initial skin grafting in the full-thickness loss burn of the hand, just as there is on the person who is treating the burnt hand prior to grafting. Such responsibility demands the maintenance of adequate range of motion during the preparatory wound care, after the important initial grafting, and during the rehabilitation period, so that maximum final function can be attained. If one does not recognize the importance of these principles of treatment, a stiff, malpositioned, contracted hand will result that is impossible to adequately correct, leading to significant permanent disability and loss of earning power. All who treat burned patients should realize that the major permanent disability of burns is in the hands. Proper treatment based on sound principles can greatly reduce or eliminate that disability.


Subject(s)
Burns/surgery , Hand Injuries/surgery , Surgery, Plastic , Burns/complications , Contracture/etiology , Contracture/prevention & control , Edema/etiology , Elasticity , Finger Joint , Hand Injuries/complications , Humans , Immobilization , Joint Diseases/etiology , Joint Diseases/prevention & control , Orthopedic Fixation Devices , Skin Transplantation , Splints , Transplantation, Autologous , Wound Healing , Wrist Joint
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