ABSTRACT
Single administrations of cortisone or phenytoin to pregnant mice on Days 11--14 of gestation caused similar skeletal and dissimilar soft tissue fetal anomalies. Cortisone reduced both maternal and fetal weight, whereas phenytoin only reduced fetal weight without adversely affecting maternal weight. A correlation between fetal weight reduction and cleft palate incidence was evident for each drug. Because probit analysis of dose--response regression lines did not deviate from parallelism after drug challenge, it was concluded that cortisone and phenytoin may produce palatal anomalies in the mouse fetus by a similar mechanism.
Subject(s)
Cortisone/toxicity , Phenytoin/toxicity , Teratogens , Animals , Body Weight/drug effects , Cleft Palate/chemically induced , Dose-Response Relationship, Drug , Female , Fetal Resorption/chemically induced , Mice , PregnancyABSTRACT
This study showed that the LD50 values for morphine sulfate, cobalt chloride, and phenytoin sodium did not vary significantly on Day 9 of gestation in CF-1 mice when compared to values of nongravid animals.
