ABSTRACT
PURPOSE: To report traumatic dislocation of a Visian Implantable Collamer Lens (ICL, STAAR Surgical Co) discovered on routine examination. METHODS: A 26-year-old man was found to have ICL subluxation into the anterior chamber with pupillary capture on routine screening examination. The patient reported being punched near the left eye 2 weeks earlier. He noted mild blurry vision, no pain, and uncorrected distance visual acuity (UDVA) was 20/30, which was decreased from his baseline of 20/20 in the affected eye. RESULTS: Surgical repositioning was performed under pupillary dilation without complication. Postoperatively, UDVA was 20/20(-2). Persistent pigment on the ICL, slight pupillary margin peaking, and anterior chamber inflammation were noted. CONCLUSIONS: Traumatic ICL dislocation may occur with minimal signs and symptoms. Education of patients about the necessity for examination after ocular trauma and need to wear eye protection during activities at high risk of ocular trauma are important.
Subject(s)
Artificial Lens Implant Migration/diagnosis , Eye Injuries/diagnosis , Phakic Intraocular Lenses , Vision Disorders/diagnosis , Wounds, Nonpenetrating/diagnosis , Adult , Artificial Lens Implant Migration/etiology , Artificial Lens Implant Migration/surgery , Eye Injuries/etiology , Eye Injuries/surgery , Humans , Male , Myopia/surgery , Reoperation , Vision Disorders/etiology , Vision Disorders/surgery , Visual Acuity , Wounds, Nonpenetrating/etiology , Wounds, Nonpenetrating/surgeryABSTRACT
PURPOSE: This study was designed to evaluate the effects of a dorzolamide-timolol combination or dorzolamide on retinal ganglion cell (RGC) density and intraocular pressure (IOP) in glaucomatous eyes of adult rats. METHODS: Glaucoma was induced in the right eye of adult Wistar rats by episcleral venous occlusion. One experimental group was administered dorzolamide 2%-timolol 0.5% combination eye drops, while the other experimental group was administered dorzolamide 2% eye drops. Control groups had surgery without drug administration. Drug application was initiated either 2 weeks before surgery (Group A), from the day of surgery (Group B), 2 weeks after surgery (Group C), or 4 weeks after surgery (Group D). RGCs were labeled by intratectal Fluorogold injections and counted from flat-mount preparations, and IOP was measured using Tonopen. RESULTS: Both dorzolamide-timolol combination and dorzolamide, when applied topically, significantly reduced IOP and improved RGC densities in experimental eyes when compared to control eyes. Earlier initiation, as well as longer duration of drug application, resulted in higher RGC densities. CONCLUSIONS: Topical application of a dorzolamide-timolol combination or dorzolamide saved RGCs to a significant extent and reduced IOP in glaucomatous rat eyes.
