ABSTRACT
Imipramine is a tricyclic medication that has been used for the treatment of depression and other mood disorders. Although rare, a slate gray discoloration of sun-exposed skin may occur in patients taking this medication. We present the case of a 63-year-old woman who had been taking imipramine for depression for more than 20 years when she developed a bluish gray discoloration on the face and neck that was diagnosed as imipramine-induced hyperpigmentation based on histopathology and clinical history. A number of other drugs that may cause hyperpigmentation also are reviewed as well as their histopathologic staining characteristics.
Subject(s)
Antidepressive Agents, Tricyclic/adverse effects , Depressive Disorder/drug therapy , Hyperpigmentation/diagnosis , Imipramine/adverse effects , Diagnosis, Differential , Face , Female , Humans , Hyperpigmentation/chemically induced , Middle Aged , NeckABSTRACT
Blue nevi are a heterogeneous group of lesions that can display a variety of different clinicopathological characteristics. Although attempts are made to classify each lesion into defined subtypes, there can be overlap between the subtypes. The clinical and histolopathologic features of common blue nevi and cellular blue nevi are discussed, as well as blue nevi with atypical features and malignant lesions with features of blue nevi.
Subject(s)
Nevus, Blue/pathology , Skin Neoplasms/pathology , HumansABSTRACT
Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare entity that typically occurs on the extremities of young females. Although linear arrangement of cutaneous lesions has been rarely reported, accompanying nail dystrophy has not been linked with this condition to our knowledge. We describe a case of linearly-oriented infiltrative papules and nodules on the index finger of a young female with associated onychodystrophy. Histology demonstrated a heavy lymphocytic infiltrate with plasma cells and proliferation of blood vessels consistent with APACHE. Our case is unique given the linear array of cutaneous lesions and associated nail dystrophy.
Subject(s)
Angiokeratoma/pathology , Nail Diseases/pathology , Pseudolymphoma/pathology , Skin Neoplasms/pathology , Angiokeratoma/complications , Angiokeratoma/diagnosis , Biopsy, Needle , Child , Female , Fingers/pathology , Humans , Immunohistochemistry , Nail Diseases/complications , Nail Diseases/diagnosis , Prognosis , Pseudolymphoma/complications , Pseudolymphoma/diagnosis , Rare Diseases , Skin Neoplasms/complications , Skin Neoplasms/diagnosisABSTRACT
We report three cases of desmoplastic trichoepithelioma (DTE) with overlying pseudocarcinomatous hyperplasia. All three cases developed on the face of patients in their second decade. In spite of their young age, a diagnosis of squamous cell carcinoma was considered for each case, given the unusual juxtaposition of these two well-known simulators of malignancy. Awareness of this potential association may avert a misdiagnosis of malignancy.
