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Angew Chem Int Ed Engl
; 62(16): e202216961, 2023 Apr 11.
Article
in English
| MEDLINE
| ID: mdl-36780188
ABSTRACT
Alkenyl boronate complexes react with acylated quinolines and isoquinolines via 1,2-metalate rearrangement to give alkylated, dearomatized heterocycles in good yields, diastereoselectivities, and regioselectivities. This multi-component coupling is highly modular and can be used to access a wide scope of heterocyclic scaffolds. Chiral boronic esters made through this methodology possess high synthetic potential and can be transformed into various functional groups in one step without racemization.