ABSTRACT
Staphylococcus aureus strains resistant to mupirocin (MIC > 4000 mg l-1) were recovered from children and staff at a school for children with eczema and/or asthma or cystic fibrosis after mupirocin had been used to treat eczematous lesions. At least three distinct strains of S. aureus were involved and resistance was shown to be due in most isolates to a transmissible plasmid. The need for monitoring the extended use of this valuable antibiotic is emphasized.
Subject(s)
Carrier State/microbiology , Mupirocin/pharmacology , Staphylococcal Infections/microbiology , Staphylococcus aureus/isolation & purification , Adolescent , Asthma , Bacteriophage Typing , Child , Cystic Fibrosis , Drug Resistance, Microbial , Eczema , Female , Humans , Male , Plasmids/genetics , Schools , Staphylococcus aureus/drug effects , Tetracycline/pharmacologySubject(s)
Electric Countershock , Family Practice , Heart Arrest/therapy , Aged , England , Humans , Male , Middle AgedABSTRACT
A male West Indian patient developed a pleural effusion without radiographic evidence of intra-thoracic lymph node or pulmonary abnormality. A pleural biopsy showed non-caseating granulomas. The Kveim test was positive. During treatment with anti-tuberculosis drugs bilateral pulmonary nodular shadows appeared in the chest x-ray. Anti-tuberculosis chemotherapy was stopped and prednisone given. The nodular shadows resolved.
