1.
Nephrol News Issues
; 4(1): 30, 1990 Jan.
Article
in English
| MEDLINE
| ID: mdl-2300215
2.
J Med Chem
; 28(6): 687-94, 1985 Jun.
Article
in English
| MEDLINE
| ID: mdl-4009589
ABSTRACT
(-)- and (+)-trachelanthic and (-)- and (+)-viridifloric acids were synthesized and their isopropylidene derivatives were regiospecifically coupled, at C-9, with (-)-retronecine obtained by hydrolysis of monocrotaline, isolated from Crotalaria spectabilis. Hydrolysis, followed by oxidation, led to the N-oxides of indicine, intermedine, lycopsamine, and the new nonnatural product, respectively. Each of these analogues was screened in the P388 lymphocytic leukemia system at the same time as indicine N-oxide, and the results were compared. Other related analogues were prepared and similarly screened and the results compared with those from indicine N-oxide.