Subject(s)
Animals, Suckling , Esophagus/drug effects , Lactation , Silicones/adverse effects , Animals , Breast Implants/adverse effects , Esophagus/chemistry , Esophagus/pathology , Female , Injections, Subcutaneous , Rats , Rats, Sprague-Dawley , Silicones/administration & dosage , Silicones/analysisABSTRACT
Thirty-six cases of hepatic toxicity associated with felbamate therapy have been collected by the Food and Drug Administration. Five patients died. We describe a case of massive acute hepatic necrosis and death within 40 days of initiation of felbamate therapy for a generalized tonic-clonic seizure disorder. We describe the clinical and histopathologic features.
Subject(s)
Anticonvulsants/adverse effects , Chemical and Drug Induced Liver Injury , Epilepsy, Tonic-Clonic/drug therapy , Liver/pathology , Propylene Glycols/adverse effects , Fatal Outcome , Felbamate , Female , Humans , Liver/drug effects , Liver Diseases/pathology , Liver Diseases/physiopathology , Liver Function Tests , Middle Aged , Necrosis , Phenylcarbamates , United States , United States Food and Drug AdministrationABSTRACT
In the decade spanning 1983 through 1992, 68 people were killed by firearms while hunting in North Carolina (average of 1.66 fatalities/100,000 licenses issued). Of these, 58 deaths involved two parties, a shooter and a victim. In 22% of the incidents the victims were mistaken for game. During the 1987-1988 hunting season a "Hunter Orange" law was initially enforced. This law requires sportsmen to wear an article of bright orange clothing while hunting. After enactment of this law, a reduction in the incidence of hunters being killed because they were "mistaken for game" has proven statistically significant. The present study documents that legally mandating bright orange clothing has resulted in fewer firearms-related fatalities due to the victim's being mistaken for game while hunting. The North Carolina experience implies that governmental intervention can influence the incidence of accidental deaths during recreational hunting.
Subject(s)
Clothing , Firearms , Recreation , Safety , Wounds, Gunshot/mortality , Wounds, Gunshot/prevention & control , Color , Humans , Legislation as Topic , North Carolina/epidemiology , Safety/legislation & jurisprudenceABSTRACT
Caterpillar bodies are eosinophilic, periodic acid-Schiff (PAS)-positive globules arranged in a linear fashion in the epidermis overlying subepidermal blisters of porphyria cutanea tarda (Am J Dermatopathol 1993;15:199-202). We retrospectively studied by transmission electron microscopy nine cases of porphyria cutanea tarda (PCT) that demonstrated caterpillar bodies. We identified three components of the eosinophilic bodies: degenerating keratinocytes, colloid bodies, and basement membrane bodies. The colloid bodies consisted of whorled masses of filaments containing degenerating melanosomes, vacuoles, mitochondria, and desmosomes. Basement membrane bodies were composed of convoluted basement membrane material and associated collagen. Both colloid and basement membrane bodies were often associated with degenerating keratinocytes, were located both intra-and extracellularly, and were occasionally fused to one another. We believe that caterpillar bodies are a combination of degenerating keratinocytes, colloid bodies, and basement membrane bodies formed by repeated blistering and reepithelialization with transepidermal migration. Furthermore, we believe that caterpillar bodies are a diagnostic clue for the diagnosis of PCT.
