ABSTRACT
Terminal Rous sarcoma virus-induced tumors in chickens had lower resistance to a pulsed current than non-terminal tumors or healthy tissues. This finding suggests the existence of some basic physiological difference between terminal and non-terminal tumors. The terminal tumors may have a higher concentration of mobile ions than either non-terminal types or healthy tissue.
Subject(s)
Chickens , Electric Conductivity , Poultry Diseases/physiopathology , Sarcoma, Avian/physiopathology , Animals , Female , Male , Poultry Diseases/genetics , Sarcoma, Avian/geneticsABSTRACT
A 51Cr uptake microcytotoxicity assay was used to determine the cytotoxicity of lymphocytes from chickens bearing Rous sarcomas. Differences in lymphocyte cytotoxicity among individual chickens were statistically significant. Lymphocytes from chickens regressing (or having regressed) their tumors were significantly more cytotoxic than lymphocytes from hosts with progressing tumors. Lymphocytes from chickens with progressing tumors tended to enhance tumor cell growth in vitro.
