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1.
Integrin-mediated ILC2 adhesion protects against lupus nephritis.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(8): 455, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38977866

Subject(s)
Integrins , Lupus Nephritis , Lupus Nephritis/immunology , Lupus Nephritis/prevention & control , Integrins/metabolism , Integrins/immunology , Integrins/antagonists & inhibitors , Animals , Humans , Mice , Cell Adhesion , Lymphocytes/immunology
2.
Pathogenic antibodies target stromal antigens in RA.
McHugh, Jessica.
Nat Rev Rheumatol ; 2024 Jul 08.
Article in English | MEDLINE | ID: mdl-38977867
3.
COVID-19 linked to rise in anti-MDA5 autoimmunity.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(7): 395, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38839847

Subject(s)
Autoimmunity , COVID-19 , Interferon-Induced Helicase, IFIH1 , SARS-CoV-2 , Humans , Interferon-Induced Helicase, IFIH1/immunology , COVID-19/immunology , COVID-19/epidemiology , Autoimmunity/immunology , SARS-CoV-2/immunology , Autoantibodies/immunology
4.
BiTEing refractory RA.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(7): 395, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38858603

Subject(s)
Arthritis, Rheumatoid , Humans , Arthritis, Rheumatoid/drug therapy , Antirheumatic Agents/therapeutic use
5.
Immunogenic Xist ribonucleoproteins drive sex-biased autoimmunity.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(4): 198, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38454055

Subject(s)
RNA, Long Noncoding , Ribonucleoproteins , Humans , Autoimmunity
6.
Factors identified that predict resolution of subclinical synovitis.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(3): 138, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38316955

Subject(s)
Arthritis, Rheumatoid , Synovitis , Humans , Synovitis/diagnostic imaging , Ultrasonography
7.
Sodium channel Nav1.7 regulates chondrocyte biology and OA progression.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(3): 137, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38326427

Subject(s)
Chondrocytes , Sodium Channels , Humans , Sodium Channels/physiology , Biology
8.
S100A4 inhibition targets fibrosis in SSc.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(2): 67, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38212540

Subject(s)
Fibroblasts , Humans , S100 Calcium-Binding Protein A4 , Fibrosis
9.
Methotrexate improves pain in hand OA.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(1): 3, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37949970

Subject(s)
Hand Joints , Methotrexate , Humans , Methotrexate/therapeutic use , Pain/drug therapy , Pain/etiology , Arthralgia , Hand
10.
Single-cell atlas unveils the diversity of RA synovial tissue.
McHugh, Jessica.
Nat Rev Rheumatol ; 20(1): 4, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38030936

Subject(s)
Arthritis, Rheumatoid , Synovial Membrane , Humans
11.
FGF signalling implicated in relapsing RA.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(11): 677, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37789118

Subject(s)
Fibroblast Growth Factors , Signal Transduction , Humans
12.
Dual inhibitor targets fibroblast metabolism in RA.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(12): 760, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37903918

Subject(s)
Arthritis, Rheumatoid , MicroRNAs , Synoviocytes , Humans , Synovial Membrane/metabolism , Arthritis, Rheumatoid/drug therapy , Arthritis, Rheumatoid/metabolism , Fibroblasts/metabolism , Synoviocytes/metabolism , Cells, Cultured , MicroRNAs/metabolism
13.
Repolarizing macrophages using antagomirs.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(10): 606, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37679591

Subject(s)
Macrophages , MicroRNAs , Humans , Antagomirs
14.
HIF-1 inhibition mitigates skin damage in CLE.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(10): 607, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37679592

Subject(s)
Lupus Erythematosus, Cutaneous , Skin , Humans
15.
Platelets promote cardiovascular complications in Kawasaki disease.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(9): 537, 2023 09.
Article in English | MEDLINE | ID: mdl-37532781

Subject(s)
Blood Platelets , Mucocutaneous Lymph Node Syndrome , Humans , Mucocutaneous Lymph Node Syndrome/complications
16.
Oral JAK inhibitor baricitinib effective in JIA.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(9): 539, 2023 09.
Article in English | MEDLINE | ID: mdl-37532782

Subject(s)
Azetidines , Janus Kinase Inhibitors , Humans , Janus Kinase Inhibitors/therapeutic use , Janus Kinase Inhibitors/pharmacology , Azetidines/therapeutic use , Sulfonamides/therapeutic use , Purines/therapeutic use
17.
New guideline for integrative approaches to RA management.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(8): 462, 2023 08.
Article in English | MEDLINE | ID: mdl-37400592
18.
New T cell target of methotrexate identified.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(8): 461, 2023 08.
Article in English | MEDLINE | ID: mdl-37430107

Subject(s)
Methotrexate , T-Lymphocytes , Humans
19.
Cognitive functional therapy improves low back pain.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(7): 397, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37286757

Subject(s)
Chronic Pain , Cognitive Behavioral Therapy , Low Back Pain , Humans , Low Back Pain/therapy , Exercise Therapy , Cognition
20.
Notch signalling mediates OA pain in mice.
McHugh, Jessica.
Nat Rev Rheumatol ; 19(7): 395, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37286758

Subject(s)
Osteoarthritis , Signal Transduction , Mice , Humans , Animals
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