ABSTRACT
We present an unusual case of multiple unilateral renal angiomyolipomas occurring together with lymphangioleiomyomatosis of the regional lymph nodes. The association of these 2 hamartomatous lesions has been described only rarely but lends support to the concept that they represent a forme fruste of the tuberous sclerosis disease complex.
Subject(s)
Hemangioma/pathology , Kidney Neoplasms/pathology , Lipoma/pathology , Lymphangiomyoma/pathology , Lymphoproliferative Disorders/pathology , Neoplasms, Multiple Primary/pathology , Female , Humans , Middle AgedABSTRACT
The pathophysiological results of a study of simultaneously freezing the pancreas and portal vein in the pig are presented. There was little reduction in portal venous flow despite the vein being frozen, and there were no cases of occlusion, rupture, or dilatation of the vein. Major histological changes in the vein wall were noted however. The frozen pancreatic tissue was completely destroyed and replaced by granulation tissue. The possible use of this form of therapy to treat pancreatic cancer is discussed.
Subject(s)
Cryosurgery , Pancreas/surgery , Portal Vein , Animals , Freezing , SwineABSTRACT
In a double-blind trial a 6% infection rate resulted from the use of a single peroperative dose of mezlocillin in emergency appendicectomy for non-perforated disease. No advantage was demonstrated by mezlocillin over the 8% infection rate achieved with metronidazole. There was only one anaerobic infection in the mezlocillin group although Bacteroides fragilis had been isolated at operation from all three infected cases and many other uninfected patients. No anaerobic infections were detected in the metronidazole group.
Subject(s)
Appendectomy , Metronidazole/therapeutic use , Mezlocillin/therapeutic use , Premedication , Surgical Wound Infection/prevention & control , Adolescent , Adult , Child , Child, Preschool , Clinical Trials as Topic , Double-Blind Method , Female , Humans , Infant , Male , Middle Aged , Random Allocation , Surgical Wound Infection/microbiologyABSTRACT
A retrospective study has been undertaken of all head and neck basal cell cancers treated at the Royal Free Hospital between 1976 and 1980 inclusive. Four methods of treatment were used during the period: simple excision with primary closure (n = 43), skin grafting or trans-position flap (n = 19), radiotherapy (n = 99), and cryosurgical ablation (n = 34). The methods were compared by observing the immediate results, the subsequent tumour recurrence rate and the length of follow-up. Statistical comparison of tumour recurrence rate showed no significant difference between treatment groups. Radiotherapy had the lowest recurrence rate (2%), but required an average of 9 out-patient treatment attendances. Excision with primary closure carried the highest recurrence rate (9.3%), whilst excision with defect closure by flap or graft, which needed a mean in-patient stay of 8.2 days, and cryosurgical treatment had similar recurrence rates of 5 to 6%. Comparing the modes of treatment, cryosurgery was quickest to perform, required no hospitalization and less than 2 out-patient treatment sessions per patient and gave the best cosmetic result. It appears to be a safe technique for treating basal cell cancers and may prove to be the most cost effective method.
Subject(s)
Carcinoma, Basal Cell/therapy , Cryosurgery , Head and Neck Neoplasms/therapy , Skin Neoplasms/therapy , Aged , Humans , Male , Retrospective StudiesABSTRACT
A case is reported of late cutaneous and muscular metastases of a uterine leiomyosarcoma following an initial simultaneous presentation with an endometrial adenocarcinoma. Such behaviour is discussed in view of the prognostic features of the original sarcoma.
