Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Neoplasm Staging , Prostatectomy/methods , Prostatic Neoplasms/radiotherapy , Prostatic Neoplasms/surgery , Antineoplastic Agents, Hormonal/therapeutic use , Atrasentan , Brachytherapy/methods , Combined Modality Therapy , Cryotherapy/methods , Humans , Laparoscopy/methods , Male , Patient Care Planning , Prognosis , Prostate-Specific Antigen/blood , Prostatic Neoplasms/drug therapy , Pyrrolidines/therapeutic use , Risk FactorsABSTRACT
Twenty bile acid or cholesterol derivatives were tested for mutagenicity by the Ames spot test procedure against five Salmonella typhimurium strains in the presence and absence of rat liver microsomes. No strong mutagens were identified, but four of the compounds increased the number of revertant colonies observed. Three of these compounds were selected for dose response experiments using the Ames plate incorporation assay procedure with strain TA 1538. No positive results were obtained. These results suggest that none of the twenty bile acid derivatives tested is likely to be the initiating agent in the aetiology of colon cancer.
Subject(s)
Bile Acids and Salts/toxicity , Cholesterol/analogs & derivatives , Mutagens , Mutation , Animals , Biotransformation , Cholesterol/toxicity , Male , Microsomes, Liver/metabolism , Mutagenicity Tests , Rats , Rats, Inbred Strains , Salmonella typhimurium/drug effects , Structure-Activity RelationshipABSTRACT
Soluble fibrinogen--fibrin complex levels were found to be significantly higher in plasma samples from pregnant women with babies suffering from intrauterine growth retardation, when compared with levels found in normal pregnancy. As soluble fibrinogen--fibrin complexes are formed following activation of the coagulation pathway in vitro and in vivo these findings may reflect the increased local intravascular coagulation within the placenta demonstrated histologically in pregnancies complicated by growth retardation. The use of more sensitive methods for detecting alterations in coagulation, fibrinolysis and platelet function may prove useful in the diagnosis of intrauterine growth retardation antenatally.
Subject(s)
Blood Coagulation Disorders/complications , Fetal Growth Retardation/etiology , Fibrin/analysis , Fibrinogen/analysis , Pregnancy Complications, Hematologic , Chromatography, Gel , Female , Humans , Placenta/blood supply , PregnancyABSTRACT
The technique of plasma fibrinogen chromatography was used to study sequential changes in coagulant and fibrinolytic activity in six patients with severe pre-eclampsia. Plasma soluble fibrinogen-fibrin complex and plasma fibrinogen-fibrin degradation product levels were measured as indices of coagulant and fibrinolytic activity respectively. Clinical deterioration antenatally was accompanied by increasing coagulant and decreasing fibrinolytic activity, while a more stable clinical picture was associated with steady coagulant and increasing fibrinolytic activity. Following delivery, a surge in fibrinolytic activity accompanied or preceded clinical recovery. The pattern of increased coagulant and diminished fibrinolytic activity would seem to favour the development of disseminated intravascular coagulation in these patients and it is possible that the balance between coagulant and fibrinolytic activity may influence the clinical course and outcome of the pregnancy.
