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Resuscitation ; 83(8): 1021-4, 2012 Aug.
Article in English | MEDLINE | ID: mdl-22445865

ABSTRACT

OBJECTIVES: This study examines the effects of IV epinephrine administration on carotid blood flow (CBF) and end tidal CO(2) (ETCO(2)) production in a swine model of active compression-decompression CPR with an impedance threshold device (ACD-CPR+ITD). METHODS: Six female swine (32 ± 1 kg) were anesthetized, intubated and ventilated. Intracranial, thoracic aorta and right atrial pressures were measured via indwelling catheters. CBF was recorded. ETCO(2), SpO(2) and EKG were monitored. V-fib was induced and went untreated for 6 min. Three minutes each of standard CPR (STD), STD-CPR+impedance threshold device (ITD) and active compression-decompression (ACD)-CPR+ITD were performed. At minute 9 of the resuscitation, 40 µg/kg of IV Epinephrine was administered and ACD-CPR+ITD was continued for 1 min. Statistical analysis was performed with a paired t-test. p values of <0.05 were considered statistically significant and all values are reported in mmHg unless otherwise noted. RESULTS: Aortic pressure, cerebral and coronary perfusion pressures increased from STD

Subject(s)
Adrenergic alpha-1 Receptor Agonists/adverse effects , Cardiopulmonary Resuscitation/instrumentation , Epinephrine/adverse effects , Heart Arrest/therapy , Hemodynamics/drug effects , Animals , Electric Impedance , Female , Heart Arrest/drug therapy , Heart Arrest/physiopathology , Swine
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