1.
Hum Mol Genet
; 1(6): 407-10, 1992 Sep.
Article
in English
| MEDLINE
| ID: mdl-1284527
ABSTRACT
cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified MboII and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.
Subject(s)
Chromosomes, Human, Pair 4 , DNA/genetics , Genes, Homeobox , Polymorphism, Restriction Fragment Length , Amino Acid Sequence , Animals , Base Sequence , Chromosome Mapping/methods , Cloning, Molecular/methods , DNA/isolation & purification , Deoxyribonucleases, Type II Site-Specific , Drosophila/genetics , Embryo, Mammalian , Embryo, Nonmammalian , Female , Gene Library , Genetic Variation , Humans , Linkage Disequilibrium , Male , Molecular Sequence Data , Oligodeoxyribonucleotides , Pedigree , RNA/genetics , RNA/isolation & purification , Restriction Mapping , Sequence Homology, Nucleic Acid
2.
Nucleic Acids Res
; 19(2): 395, 1991 Jan 25.
Article
in English
| MEDLINE
| ID: mdl-1849630
