1.
Org Lett
; 26(23): 4975-4979, 2024 Jun 14.
Article
in English
| MEDLINE
| ID: mdl-38829188
ABSTRACT
Chiral Cu(II) bisoxazolines have been shown to catalyze the coupling of acetyl-protected carbohydrates with N-silylated indoles to give the corresponding N-glycosides. Preliminary mechanistic experiments indicated that catalysis occurs through formation of a Cu-indolide complex with concomitant formation of TMS-OTf which together activate the sugar and deliver the indole nucleophile.