1.
2.
Anal Chem
; 57(1): 295-302, 1985 Jan.
Article
in English
| MEDLINE
| ID: mdl-3985338
Subject(s)
Cystic Fibrosis/genetics , Genetic Carrier Screening , Cells, Cultured , Chromatography, Gas/methods , Female , Humans , Male
3.
J Med Chem
; 27(10): 1367-9, 1984 Oct.
Article
in English
| MEDLINE
| ID: mdl-6090666
ABSTRACT
We have hypothesized that the biological activity of the antiviral antitumor diterpene aphidicolin requires a specific stereochemical relationship between two rigidly held hydroxyl groups on the alpha face of the molecule. The complex tetracyclic carbon skeleton is not necessary but appears to serve only as a framework on which to hold the hydroxyls. In support of this theory, we have prepared a simple tricyclic triol analogue (7) whose activity approaches that of the natural product in inhibiting in vitro DNA synthesis.
Subject(s)
Antiviral Agents/chemical synthesis , DNA Replication/drug effects , Diterpenes , Aphidicolin , Cell Line , Cell Transformation, Viral , Chemical Phenomena , Chemistry , Diterpenes/chemical synthesis , Diterpenes/pharmacology , Humans , Indicators and Reagents , Lung , Magnetic Resonance Spectroscopy , Simian virus 40/genetics , Spectrophotometry, Infrared , Structure-Activity Relationship
4.
J Org Chem
; 41(25): 3953-5, 1976 Dec 10.
Article
in English
| MEDLINE
| ID: mdl-993896