1.
Conf Proc IEEE Eng Med Biol Soc
; 2006: 4010-5, 2006.
Article
in English
| MEDLINE
| ID: mdl-17946595
ABSTRACT
Several important non-cardiac drugs have been removed from the market after revealing harmful effect that was not identified during prior safety-assessment studies. We developed a new technique for the measurements of repolarization abnormalities from surface ECGs; this method improves sensitivity and specificity of the current technique used to identify the presence of abnormal ion current kinetics in the myocardial cells namely a prolongation of the QT interval on the surface ECG signal. We described in this paper the method and preliminary results, revealing the superiority of our technique that may play a role in the future of drug-safety assessment.
Subject(s)
Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/physiopathology , Aza Compounds/adverse effects , Delayed Rectifier Potassium Channels/physiology , Electrocardiography/methods , Quinolines/adverse effects , Adult , Anti-Infective Agents/adverse effects , Delayed Rectifier Potassium Channels/drug effects , Female , Fluoroquinolones , Humans , Long QT Syndrome/chemically induced , Long QT Syndrome/physiopathology , Male , Moxifloxacin , Placebos
2.
Eur J Cancer (1965)
; 16(7): 901-7, 1980 Jul.
Article
in English
| MEDLINE
| ID: mdl-7428784
3.
Eur J Cancer (1965)
; 14(2): 141-6, 1978 Feb.
Article
in English
| MEDLINE
| ID: mdl-624311