[Tyrosine inhibition of anaphylactic shock in guinea pigs]. / Ingibitsiia anafilakticheskogo shoka tirozinom u morskikh svinok.

Experimental investigations on guinea-pigs were carried out to study the role of tyrosine in the prevention of anaphylaxis. It should be noted that the intensity of clinical manifestations of anaphylactic shock was reduced in 5 out of 24 L-tyrosine fed guinea-pigs (20.83%), while in 9 animals (37.5%) anaphylactic shock did not develop. 100% death of control animals was registered. The effect of tyrosine was absent only in 10 guinea-pigs. Positive effect of tyrosine was followed by tyrosine-aminotransferase activation with a tendency towards the decrease in tyrosine plasma level and the rise in cortisol blood level. It is suggested that tyrosine increases glucocorticoid secretion of the adrenal cortex: Glucocorticoids in their turn, enhance tyrosine-aminotransferase activity in the animal liver.

[Effect of papain and levamisole on the body's immunological indices and oxidation-reduction processes in experimental sensitization]. / Vliianie papaina i levamizola na immunologicheskie pokazateli i okislitel'no-vosstanovitel'nye protsessy organizma v usloviiakh éksperimental'noi sensibilizatsii.

The effect of papain on sensitized animals was evident from activation of oxidation processes in the liver and adrenal glands, increased ability of the host to develop cellular immunity reactions, a moderate decrease in the level of humoral antibodies and inactivation of the monooxygenase system of the liver and adrenal glands. Levamisol had a favourable effect on the immunological reactions and monooxygenase system. However, it induced an increase in tissue hypoxia of the organs.