A translocation t (Bq+: cq-) in a West Indian family and a report of a second family showing a possible long arm group B translocation

Two patients with abnormalities of the long arm of a B autosome are described: an infant with multiple abnormalities, physical and histological, and a phenotypically normal adult male with a family history of high infant loss and the father of 4 abortions. In the first case the abnormality was due to a balanced translocation in the mother and grandfather, between a B and a C autosome. In the second case there was mosaicism, but the origin of the abnormality was not determined. The abnormalities in the first case are compared with other previous reports of abnormalities of C and B chromosomes, and the segregation of gametes in the family is discussed.(AU)