ABSTRACT
A literatura de cordel é um gênero literário popular com raízes no Nordeste brasileiro. Com o propósito de desenvolver metodologias participativas, no contexto de uma disciplina na Pós-Graduação stricto sensu em Saúde Coletiva, elaborou-se um folheto inspirado na obra "A Elite do Atraso: da escravidão à lava-jato" do sociólogo brasileiro Jessé Souza. O objetivo foi apresentar os capítulos do livro em forma de recital, utilizando a literatura de cordel, para discussão do tema de forma dinâmica em espaços de produção de conhecimento nos campos da Educação e da Saúde. A obra construída retrata, de forma crítica, a construção histórica do Brasil mediante seu berço, pautada nas injustiças sociais trazidas com os colonizadores, formuladas pela escravidão que hoje reverbera de forma atualizada nas crises política, econômica e de classes.
Cordel literature is a popular literary genre with roots in the northeast of Brazil. With the aim of developing participatory methodologies for a subject on a Master's degree in Public Health, we produced a pamphlet inspired by the book "A Elite do Atraso: da escravidão a lava-jato" (The Elite of Backwardness: from slavery to the car wash scandal), by Brazilian sociologist Jessé Souza. The aim of the pamphlet was to present each of the chapters of the book in the form of a recital using cordel literature to promote dynamic discussion of the theme in spaces of knowledge production in the fields of health and education. The pamphlet critically depicts the historic construction of Brazil from the cradle, grounded on social injustice brought by the colonizers and shaped by slavery, which continues to reverberate today, reframed through the political, economic and class crisis.
La literatura de cordel es un género literario popular con raíces en el nordeste brasileño. Con el propósito de desarrollar metodologías participativas, en el contexto de una asignatura en el postgrado stricto sensu en Salud Colectiva, se elaboró un folleto inspirado en la obra "A Elite do Atraso: da escravidão a lava-jato" del sociólogo brasileño Jessé Souza. El objetivo fue presentar los capítulos del libro en forma de recital, utilizando la literatura de cordel, para discusión del tema de forma dinámica en espacios de producción de conocimiento en los campos de la educación y de la salud. La obra construida retrata, de forma crítica, la construcción histórica de Brasil por medio de su cuna, con base en las injusticias sociales traídas por los colonizadores, formulada por la esclavitud que hoy día reverbera de forma actualizada en la crisis política, económica y de clases.
ABSTRACT
Discovery of the rapid antidepressant effect of ketamine has been considered one of the most important advances in major depressive disorder treatment. Several studies report a significant benefit to patients that lasts up to 19 days after treatment. However, concerns arise from the long-term use of ketamine, thus a safe and effective strategy for maintaining its antidepressant effect is still necessary. To this end, our work assessed the effects of imipramine and fluoxetine after repeated ketamine treatment in male mice. Ketamine (30 mg/kg/day for 14 days) induced an anti-immobility effect in the forced swimming (FS) paradigm, detected 1 and 3 days after treatment. Seven days after the last ketamine injection, mice received imipramine (20 mg/kg) or fluoxetine (30 mg/kg). Imipramine and fluoxetine did not change mice's immobility time, regardless of the pre-treatment (saline or ketamine). Since both drugs' anti-immobility effect was demonstrated in the classical FS test, we can assume that repeated exposure to intermittent stress inhibited the antidepressant drugs' anti-immobility effects. Moreover, pre-exposure to ketamine did not counteract stress-induced changes in mice response to antidepressants. Since exposure to forced swim and i.p. injections are stressful to rodents, each stressor's contribution to the blunted response to antidepressants was investigated. Our data demonstrated that both stressors (FS and i.p. injections) influenced the reported effect. In summary, our results showed that exposure to intermittent repeated stress inhibited the anti-immobility effect of imipramine and fluoxetine in mice and corroborated findings demonstrating that exposure to stress can blunt patients' response to antidepressants.
