[Severe acute kidney injury in critically ill children: Epidemiology and prognostic factors]. / Daño renal agudo grave en niños críticos: epidemiología y factores pronósticos.

INTRODUCTION: Acute kidney injury (AKI) is a severe complication in critically ill children. The aim of the study was to describe the characteristics of AKI, as well as to analyse the prognostic factors for mortality and renal replacement therapy (RRT) in children admitted to Paediatric Intensive Care Units (PICUs) in Spain. PATIENTS AND METHODS: Prospective observational multicentre study including children from 7 days to 16 years old who were admitted to a PICU. A univariate and multivariate logistic regression analysis of the risk factors for mortality and renal replacement therapy at PICU discharge were performed. RESULTS: A total of 139 cases of AKI were analysed. RRT was necessary in 60.1% of cases. Mortality rate was 32.6%. At PICU discharge RRT was necessary in 15% of survivors. Thrombopenia and low creatinine clearance values were prognostic markers of RRT at PICU discharge. High values of platelets, serum creatinine and weight were associated with higher survival. CONCLUSIONS: Critically ill children with AKI had a high mortality and morbidity rate. Platelet values and creatinine clearance are markers of RRT at PICU discharge, whereas number of platelets, serum creatinine and weight were associated with mortality.

[Ventilation in special situations. Mechanical ventilation in acute respiratory distress syndrome/acute pulmonary lesion]. / Ventilación en situaciones especiales. Ventilación mecánica en el síndrome de dificultad respiratoria aguda/lesión pulmonar aguda.

Acute respiratory distress syndrome (ARDS), which was first described by Ashbaugh in 1967, consists of acute hypoxemic respiratory failure (PaO2/FiO2< or =200) associated with bilateral infiltrates on the chest radiograph caused by noncardiac diffuse pulmonary edema. Although ARDS is of multiple etiology, pulmonary or extrapulmonary injury can produce systemic inflammatory response that perpetuates lung disturbances once the initial cause has been eliminated. Most patients with ARDS require mechanical ventilation. Currently, the old standard is conventional ventilation optimized to protect against ventilator-associated lung injury. Other mechanical ventilation strategies such as high-frequency oscillatory ventilation, which is also based on alveolar recruitment and adequate lung volume, can be useful alternatives. In this review, the level of evidence for other therapies, such as prone positioning, nitric oxide and prostacyclin inhalation, exogenous surfactant, and extracorporeal vital support techniques are also analyzed.

[Ventilation in special situations. Mechanical ventilation during transportation of pediatric patients]. / Ventilación en situaciones especiales. Ventilación mecánica durante el transporte pediátrico.

Most severe pediatric injuries occur far from regional centres specialized in the definitive care of the critically-ill child. Adequate initial stabilization and an appropriate transport system significantly decrease morbidity and mortality in these patients. In the last few years, technological developments have improved the quality of medical transportation. Mechanical ventilation is one of the elements that has been affected by these advances with portable ventilators and monitoring systems that are increasingly similar to those used in pediatric intensive care units. To prevent complications from developing during transportation, adequate preparation is required consisting of (i) prior stabilization of the patient, (ii) assessment of potential risks and specific needs, (iii) monitoring, (iv) transport preparation, and (v) assessment of vital signs and patient management. Portable ventilators are designed to be used for short periods under difficult conditions (temperature changes, altitude, rain, knocks, etc.). Consequently they should have specific common characteristics: portability, resistance, ease of handling, low electricity and gas consumption, and safety. They should also be easy to set up. Their programming is generally similar to that of conventional ventilators and should be based on the physiologic characteristics of the child according to age and underlying process.