ABSTRACT
The objective of the present work was to analyze the current concept of the genetically predetermined condition Zivert-Kartagener's syndrome with special reference to the pathogenetic mechanisms underlying the development of this condition, its clinical picture and methods of treatment. The authors' original observations of the patients presenting with Zivert-Kartagener's syndrome are reported.
Subject(s)
Dextrocardia/diagnostic imaging , Infertility , Kartagener Syndrome , Mucociliary Clearance/genetics , Rhinitis , Sinusitis , Chronic Disease , Disease Management , Dyneins/genetics , Female , Humans , Infertility/diagnosis , Infertility/etiology , Kartagener Syndrome/diagnosis , Kartagener Syndrome/physiopathology , Kartagener Syndrome/therapy , Mutation , Prognosis , Rhinitis/diagnosis , Rhinitis/etiology , Rhinitis/physiopathology , Rhinitis/therapy , Sinusitis/diagnosis , Sinusitis/etiology , Sinusitis/physiopathology , Sinusitis/therapy , Suppuration/physiopathology , Young AdultABSTRACT
The authors present the currently available data on mucoviscidosis (cystic fibrosis) based on their original experience and the review of the relevant literature. Special attention is given to the pathogenetic mechanisms underlying the development of this condition, its diagnostics, and methods of treatment as exemplified by the clinical case of cystic fibrosis in an adult patient.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Cystic Fibrosis , Exocrine Pancreatic Insufficiency , Pseudomonas aeruginosa , Respiratory System Agents/therapeutic use , Respiratory Tract Infections , Adult , Bronchoscopy/methods , Cystic Fibrosis/diagnosis , Cystic Fibrosis/etiology , Cystic Fibrosis/physiopathology , Cystic Fibrosis/therapy , Cystic Fibrosis Transmembrane Conductance Regulator/genetics , Disease Management , Exocrine Pancreatic Insufficiency/diagnosis , Exocrine Pancreatic Insufficiency/physiopathology , Exocrine Pancreatic Insufficiency/therapy , Humans , Male , Microbial Sensitivity Tests/methods , Mutation , Pseudomonas aeruginosa/drug effects , Pseudomonas aeruginosa/isolation & purification , Respiratory Tract Infections/diagnosis , Respiratory Tract Infections/drug therapy , Respiratory Tract Infections/microbiology , Treatment OutcomeABSTRACT
Tuberculous lesions of the liver frequently occur in autopsy material, even though most of them are clinically unapparent. Pathogenetically, hepatic tuberculosis is a manifestation of general military tuberculosis with the infection brought in through the hematogenous route (through the hepatic artery or the portal system) as a result of intestinal or mesenteric lymph node tuberculosis. We report a case of combination of hepatic tuberculosis and diabetes mellitus in a young woman with reference to the clinical course of the disease, its diagnostics and treatment.
