ABSTRACT
The COVID-19 pandemic caused by the SARS-CoV-2 virus has generated globally more than 110.7 million infections and 2.4 million deaths. The severity of this infection can range from asymptomatic, mild to severe. To know the possible associations between the presence of the virus and histopathological alterations found in tissues of fatal cases of COVID-19, the presence of the virus in the lung tissue of a patient with a clinical history of SARS-CoV-2 infection was evaluated. Lung tissue was histologically processed for immunohistochemical detection of SARSCoV-2. In the histopathological study, morphological changes associated with pneumonitis of viral origin were observed. Likewise, the location of the SARS-CoV-2 virus was observed mainly in the cytoplasm of the cells of the inflammatory infiltrate.
La pandemia de COVID-19 causada por el virus SARS-CoV-2 ha generado más de 110,7 millones de infecciones y 2,4 millones de muertes a nivel mundial. Esta infección puede ser asintomática y sus manifestaciones clínicas pueden variar entre leves y graves. Para conocer las posibles asociaciones entre la presencia del virus y las alteraciones histopatológicas encontradas en los tejidos de casos fatales de COVID-19, se evaluó la presencia del virus en el tejido pulmonar de un paciente con antecedentes clínicos de infección por SARS-CoV-2. La muestra se procesó para la detección inmunohistoquímica del virus. En el estudio histopatológico, se observaron cambios morfológicos asociados con neumonitis de origen viral. Asimismo, el virus se localizó principalmente en el citoplasma de las células del infiltrado inflamatorio.
Subject(s)
COVID-19 , Pandemics , Humans , SARS-CoV-2 , LungABSTRACT
The COVID-19 pandemic caused by the SARS-CoV-2 virus has generated globally more than 110.7 million infections and 2.4 million deaths. The severity of this infection can range from asymptomatic, mild to severe. To know the possible associations between the presence of the virus and histopathological alterations found in tissues of fatal cases of COVID-19, the presence of the virus in the lung tissue of a patient with a clinical history of SARS-CoV-2 infection was evaluated. Lung tissue was histologically processed for immunohistochemical detection of SARS- CoV-2. In the histopathological study, morphological changes associated with pneumonitis of viral origin were observed. Likewise, the location of the SARS-CoV-2 virus was observed mainly in the cytoplasm of the cells of the inflammatory infiltrate.
La pandemia de COVID-19 causada por el virus SARS-CoV-2 ha generado más de 110,7 millones de infecciones y 2,4 millones de muertes a nivel mundial. Esta infección puede ser asintomática y sus manifestaciones clínicas pueden variar entre leves y graves. Para conocer las posibles asociaciones entre la presencia del virus y las alteraciones histopatológicas encontradas en los tejidos de casos fatales de COVID-19, se evaluó la presencia del virus en el tejido pulmonar de un paciente con antecedentes clínicos de infección por SARS-CoV-2. La muestra se procesó para la detección inmunohistoquímica del virus. En el estudio histopatológico, se observaron cambios morfológicos asociados con neumonitis de origen viral. Asimismo, el virus se localizó principalmente en el citoplasma de las células del infiltrado inflamatorio.
Subject(s)
COVID-19 , Lung , Immunohistochemistry , Antigens, ViralABSTRACT
A 50-year-old woman presented to the emergency room complaining of severe headache. A non-contrasted head CT was obtained, which demonstrated a hyperdense image compatible with an intracerebral hemorrhage in the posterior region of the left temporal lobe. The patient displayed no neurological deficit during the consultation and a subsequent MRI showed a temporoinsular bleeding lesion that was suggestive of an atypic meningioma or a metastatic lesion. Afterwards, neck, chest and abdomen CT scans were performed, and the imaging ruled out a secondary neoplasm. The patient underwent surgical resection of the lesion, and a solid tumor was found with no bleeding associated. The pathology reported a WHO I fibroblastic meningioma.
ABSTRACT
Primary Burkitt´s lymphoma (BL) of the prostate is rare in the adolescent population. The etiology remains poorly understood. There has been some proposed associations to Epstein-Barr virus and HIV. Clinical and histopathologic data of a 17-year-old patient who underwent transurethral resection of the prostate was obtained. We report the first case of primary malignant BL of the prostate in a 17-year-old Caucasian male who presented with hematuria, lower urinary tract symptoms. Differential diagnosis of a prostatic mass in adolescent patients must be primary or secondary lymphoma of the prostate, including BL as described for the first time in this article.
Subject(s)
Burkitt Lymphoma/diagnosis , Prostatic Neoplasms/diagnosis , Adolescent , Biopsy , Burkitt Lymphoma/pathology , Burkitt Lymphoma/surgery , Diagnosis, Differential , Humans , Male , Prostate/pathology , Prostate/surgery , Prostatic Neoplasms/pathology , Prostatic Neoplasms/surgery , Rhabdomyosarcoma/diagnosis , Transurethral Resection of Prostate , Urinary Bladder Neoplasms/diagnosisABSTRACT
BACKGROUND: Primary neuroendocrine carcinoma of the breast is a heterogeneous group of rare tumors with positive immunoreactivity to neuroendocrine markers in at least 50% of cells. Diagnosis also requires that other primary sites be ruled out and that the same tumor show histological evidence of a breast in situ component. Primary neuroendocrine carcinoma of the breast rarely presents as locally advanced disease and less frequently with such widespread metastatic disease as described herein. The review accompanying this case report is the first to provide an overview of all the cases of primary neuroendocrine carcinoma of the breast published in the literature and encompasses detailed information regarding epidemiology, histogenesis, clinical and histologic diagnosis criteria, classification, surgical and adjuvant treatment, as well as prognosis. We also provide recommendations for common clinical and histologic pitfalls associated with this tumor. CASE PRESENTATION: We describe a case of a 51-year-old Hispanic woman initially diagnosed with locally-advanced invasive ductal carcinoma that did not respond to neoadjuvant treatment. After undergoing modified radical mastectomy the final surgical pathology showed evidence of alveolar-type primary neuroendocrine carcinoma of the breast. The patient was treated with cisplatin/etoposide followed by paclitaxel/carboplatinum. Thirteen months after surgery the patient is alive, but developed pulmonary, bone, and hepatic metastasis. CONCLUSION: The breast in situ component of primary neuroendocrine carcinoma of the breast may prevail on a core biopsy samples increasing the probability of underdiagnosing this tumor preoperatively. Being aware of the existence of this disease allows for timely diagnosis and management. Optimal treatment requires simultaneous consideration of both the neuroendocrine and breast in situ tumor features.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/diagnosis , Carcinoma, Ductal, Breast/diagnosis , Carcinoma, Neuroendocrine/diagnosis , Bone Neoplasms/secondary , Bone Neoplasms/therapy , Breast Neoplasms/therapy , Carboplatin/administration & dosage , Carcinoma, Ductal, Breast/therapy , Carcinoma, Neuroendocrine/therapy , Cisplatin/administration & dosage , Combined Modality Therapy , Diagnosis, Differential , Etoposide/administration & dosage , Female , Humans , Liver Neoplasms/secondary , Liver Neoplasms/therapy , Lung Neoplasms/secondary , Lung Neoplasms/therapy , Magnetic Resonance Imaging , Mastectomy , Middle Aged , Neoadjuvant Therapy , Neoplasm Staging , Paclitaxel/administration & dosage , Prognosis , Review Literature as TopicABSTRACT
El síndrome de reconstitución inmunológica inflamatorio (SRII) la infección por el virus de inmunodeficiencia humana, VIH, es una entidad clínica rara caracterizada por la recuperación del sistema inmune reflejada en un dramático aumento del conteo linfocitario T CD4+ y disminución de la carga viral del VIH en suero al corto tiempo de haber iniciado o reini¬ciado terapia antirretroviral altamente efectiva TARAE. Usualmente se manifiesta con un deterioro paradójico del estado del paciente secundario en la mayoría de los casos a una activación o reactivación de procesos infecciosos oportunistas que se encontraban silentes o en estado de remisión y puede comprometer la integridad de cualquier sistema en el orga¬nismo, incluyendo el sistema nervioso central, cuyo compromiso es inusual. A continuación expondremos el caso de un paciente a quien se le diagnosticó leucoencefalopatía multifocal progresiva como parte de este síndrome, que posterior a la suspensión temporal del tratamiento antirretroviral, administración de esteroides y de mirtazapina, mostró estabilización clínica de la enfermedad.
Subject(s)
Humans , HIV , Infections , Colombia , NeurologyABSTRACT
La gastritis crónica atrófica multifocal con metaplasia intestinal es considerada como un paso evolutivo en el desarrollo del carcinoma gástrico, principalmente en las áreas geográficas de alto riesgo donde tiene el carácter de enfermedad endémica. Estas se dividen en metaplasia intestinal completa y metaplasia intestinal incompleta; esta última es la que tiene mayor tendencia a presentar cambios displásicos y evolucionar a lesiones neoplásicas malignas. la distinción entre los dos tipos se hace con base en el aspecto morfológico y terapéutico que reviste este hallazgo, es deseable emplear técnicas especiales que den una mayor precisión al patólogo para comprometer un diagnóstico confiable. En este trabajo, comparamos la concordancia en la clasificación de la metaplasia intestinal en el tejido obtenido por biopsia y coloreado con hematoxilina y eosina y la coloración espacial del mismo tejido con HID (High Iron Diamine) la cual detecta la producción de sulfomucinas por reacción inmunoenzimática, rasgo distintivo de la metaplasia intestinal incompleta. El coeficiente de kappa mostró una concordancia moderada, menor que la esperada por el efecto del azar, por lo que consideramos que esta técnica debe ser empleada para la apropiada tipificación de este transtorno o, por lo menos, resevarlo para los casos de mayor dificultad diagnóstica.
