ABSTRACT
PURPOSE: The basic objective of this study is to develop the Flurbiprofen sodium soluble ocusert to increase patient compliance by improving local delivery of the drug. MATERIALS AND METHODS: Three different polymers were used in combination to prepare the rate controlling membrane. The drug reservoir was prepared by using hydroxy propyl methyl cellulose. Ocuserts were evaluated for their physicochemical parameters. The optimized formulations were further evaluated for accelerated stability studies, eye irritancy tests, and for in vivo drug release studies. RESULTS: Ocuserts were found stable at room temperature and showed a strong positive correlation between in vitro and in vivo drug release. CONCLUSION: An appropriate combination of hydrophilic and hydrophobic polymers provides better control of drug delivery.
Subject(s)
Acrylic Resins/chemistry , Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , Cellulose/analogs & derivatives , Drug Delivery Systems , Flurbiprofen/pharmacokinetics , Methylcellulose/analogs & derivatives , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Cellulose/chemistry , Drug Carriers , Drug Design , Drug Evaluation , Female , Flurbiprofen/administration & dosage , Flurbiprofen/chemistry , Hydrogen-Ion Concentration , Hypromellose Derivatives , Male , Methylcellulose/chemistry , Patient Compliance , Rabbits , TemperatureABSTRACT
We present a case of oleander leaf extract poisoning manifested by vomiting, lightheadedness, and heart block. Practicing physicians should understand the potential lethal properties of oleander and its availability throughout the world.
