Latent celiac disease in reproductive performance of women.

OBJECTIVE: To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance. DESIGN: Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery. SETTING: Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi. PATIENT(S): Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy. RESULT(S): The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects. CONCLUSION(S): Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.

Calcium in midpregnancy.

OBJECTIVE: To establish reference value for serum calcium concentration and urinary calcium excretion during mid pregnancy and to find out variation of calcium intake in pregnant women. MATERIALS AND METHODS: This was a cross sectional study conducted in antenatal clinic of department of Obstetrics and Gynaecology. A total of 543 pregnant women with pregnancy period of second trimester were enrolled for the study. Eligible healthy, vegetarian primigravid women provided serum and 24 h urinary samples for determination of serum calcium and urinary calcium excretion. Dietary intake calculated by 3-day recall method. Variation of calcium intake according to various demographic characteristics was noted. RESULTS: Statistical analysis done with SPSS software. The mean total serum calcium and 24 h urinary calcium and dietary intake of calcium were 8.1+/-1.5 mg/dl (5.1-11.9), 129.56+/-67.08 mg (40.5-400) and 324.37+/-199.47 mg/day (85.71-910.71) respectively. The 95th percentiles for serum calcium were 10.56 mg/dl and urinary calcium excretion was 280.70 mg/24 h. Educational level, monthly income and height were positive correlated with calcium intake. CONCLUSION: This preliminary study defines the first standard value for calcium status in pregnant second trimester females of northern India. Calcium intake in pregnant females is affected by various demographic characteristics. There is need to change dietary pattern by improving education and socio-economic level.