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J Invest Dermatol ; 128(11): 2569-2571, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18927538

ABSTRACT

Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.


Subject(s)
Dermatitis, Atopic/etiology , Dermatitis, Atopic/immunology , Interleukin-17/metabolism , T-Lymphocytes, Helper-Inducer/metabolism , CD4-Positive T-Lymphocytes/immunology , Disease Progression , Humans , Severity of Illness Index , Th1 Cells/metabolism , Th2 Cells/metabolism
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