Concentration of Potentially Toxic Elements (PTEs) in Rapid Coffee Products in Bandar Abbas, Iran: Probabilistic Non-Carcinogenic and Carcinogenic Risk Assessment.

Coffee is one of the most widely consumed beverages in the world. However, coffee plants are often exposed to potentially toxic elements (PTEs) pollution. The main aims of current study were to detect the PTEs in instant coffee and health risk assessment of consumers in Bandar Abbas city. To achieve this, 40 samples of instant coffee were randomly collected from various points in the city in 2023 and PTEs concentrations were measured using flame atomic absorption spectrometry (FAAS). The non-carcinogenic and carcinogenic risks were calculated using Monte Carlo simulation (MCS) method. The concentrations of Fe and Cu were higher than other PTEs, equaling 404.41 mg/kg and 0.0046 mg/kg, respectively. The non-carcinogenic risk assessment revealed that THQ (Fe > Pb > As > Cd > Ni > Cu) and TTHQ levels were less than 1 based on the 95% percentile in adults and children, indicating there is no possibility of a non-carcinogenic risk associated with instant coffee. The carcinogenic risk due to inorganic As in instant coffee was acceptable (2.63E-5 and 1.27E-5 based on the 95% percentile for adults and children, respectively), therefore PTEs in instant coffee do not endanger the health of consumers.

The concentration of potentially toxic elements (PTEs) in honey: Global systematic review and meta-analysis and risk assessment.

The papers were searched in databases including PubMed, Scopus, Web of science, Embase, Science Direct until 21 September 2023 and meta-analysis of concentration of PTEs in honey was performed using random effects model based on country subgroups. The non-carcinogenic risk and carcinogenic risk were calculated by Target Hazard Quotient (THQ) and Cancer Risk (CR), respectively. The sort of PTEs in honey based on pooled concentration was Cu (1.10E + 02 µg/kg) > Ni (1.80E + 01 µg/kg) > Pb (2.60E + 00 µg/kg) > Hg (1.50E + 00 µg/kg) > Cd (5.10E-01 µg/kg) > As (4.80E-01 µg/kg). The concentration of PTEs in the countries of Ethiopia (As), Jordan (Cd and Pb), Thailand (Ni), Brazil (Cu and MeHg) was observed to be higher than other countries. The non-carcinogenic risk was less than 1, hence, the consumption of honey does not have non-carcinogenic risk. Except children in Nigeria, CR due to iAs in honey was acceptable for the both adults and children in the other countries, Therefore, the consumption of honey does not have carcinogenic risk.

The concentration of pesticides in onion samples from Iran: a non-carcinogenic health risk assessment.

Pesticide residues were extracted using the QuEChERS method, followed by detection by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The non-carcinogenic health risk in adult and child consumers was calculated by target hazard quotient (THQ) and total target hazard quotient (TTHQ) in the Monte Carlo Simulation (MCS) method. The rank order of pesticides detected by UHPLC-MS/MS based on median concentration in onion was tebuconazole (0.004551 mg/kg) > imidacloprid (0.00233 mg/kg) > boscalid (0.00211 mg/kg) > diazinon (0.00079 mg/kg) > thiabendazole (0.00075 mg/kg) > acetamiprid (0.00052 mg/kg) > thiophanate-methyl (0.00052 mg/kg) > dichlorvos (0.000349 mg/kg) > fenitrothion (0.000132 mg/kg) > penconazole (0.00005 mg/kg). The median of TTHQ in adults and children's consumers were 4.00E-3 and 2.00E-2, respectively. TTHQ in adults and children's consumers was lower than 1 value. Hence, consumers were in the acceptable range (TTHQ <1). Consequently, onion consumption cannot endanger consumers' health status due to the pesticide residues.

Concentration of potentially toxic elements in fillet shrimps of Mediterranean Sea: Systematic review, meta-analysis and health risk assessment.

In this study, an attempt was made to meta-analyzed the concentration of potentially toxic elements (PTEs) in shrimps tissue of Mediterranean Sea and health risk of consumers was estimated. Search was conducted in international databases includes Scopus, PubMed, Embase, Science Direct and Web of Science from 1 January 2010 to 20 July 2023. The random effects model used to meta-analysis of concentration of PTEs in shrimp in subgroups. In addition, non-carcinogenic and carcinogenic risks for adults and children were calculated using target hazard quotient (THQ) and cancer risk (CR). Meta-analysis concentration of PTEs in shrimps was conducted using random effects model based on country subgroups. The rank order of PTEs based on mean (pooled) level in fillet of shrimps was Fe (15.395 mg/kg-ww) > Zn (10.428 mg/kg-ww) > Cu (6.941 mg/kg-ww) Pb (5.7 mg/kg-ww) > Ni (1.115 mg/kg-ww) > As (0.681 mg/kg-ww) > Cd (0.412 mg/kg-ww) > Hg (0.300 mg/kg-ww). THQ level in adults and children due to Cd and Pb in Italy was higher than 1 value. THQ level in adults and children due to Cu, Ni, Fe, Zn and inorganic As was lower than 1 value. CR due to inorganic As in Greece and Türkiye for adults and children was higher than 1E-6 value. Therefore, it was recommended to continuously monitor and reduce the concentration of PTEs in shrimps in Italy, Greece and Türkiye, especially.

A probabilistic health risk assessment of potentially toxic elements in edible vegetable oils consumed in Hamadan, Iran.

In this study, potential toxic element (PTEs) including lead (Pb), arsenic (As), cadmium(Cd), iron (Fe) and zinc (Zn) in traditional and industrial edible vegetable oils (peanut, sunflower, olive and sesame) collected from Hamadan, west of Iran were determined using Inductivity Coupled Plasma Optical Emission Spectrometry (ICP-OES). Besides, probabilistic health risk assessment (non-carcinogenic and carcinogenic risks) was identified via total target hazard quotient (TTHQ) and cancer risk (CR) by the Monte Carlo Simulation (MCS) model. The ranking of concentration PTEs in traditional and industrial edible vegetable oils was Fe > Zn > As > Pb > Cd. The in all samples, content of PTEs in industrial oils were upper than traditional oils (p < 0.001). The level of PTEs in most of vegetable oils was lower than permissible concentration regulated by Codex and national standard. In term of non-carcinogenic, consumers were at acceptable range (TTHQ < 1) due to ingestion both traditional and industrial vegetable oils content of PTEs. In term of carcinogenic, CR the both adults and children was higher than acceptable range (CR < 1E-6), Hence consumer are at unacceptable risk due to ingestion industrial vegetable oils content of inorganic As. Therefore, it is recommended to implement control plans for PTEs in vegetable oils consumed in Hamadan, Iran.

Concentration of Heavy Metals in Traditional and Industrial Fruit Juices from Iran: Probabilistic Risk Assessment Study.

Exposure to heavy metals can endanger the health of exposed people in the long term. The consumption of fruit juice is increasing; it is important to estimate the health risk of consumers due to heavy metals. The current study was carried out for the analysis of toxic metals (lead (Pb), arsenic (As), and cadmium (Cd)) and essential elements (copper (Cu) and zinc (Zn)) in 60 samples of traditional and industrial fruit juices (10 samples of different brands of apple, orange, grape, peach, mango, and pineapple) in Hamadan, West Iran, using inductivity coupled plasma optical emission spectrometry (ICP-OES) method. The validation protocol included precision of the analytical method; recovery, the determination of the limit of detection (LOD), the limit of quantification (LOQ), and linearity were measured. Moreover, risk assessment was detected using target hazard quotient (THQ) and cancer risk (CR) by the Monte Carlo simulation (MCS) model. The ranking of metal concentration in traditional and industrial fruit juices was Zn > Cu > As > Pb > Cd. In all samples, concentrations of heavy metals in industrial fruit juices were higher than traditional fruit juices p < < 0.001. The level of metals in all samples was lower of the US Environmental Protection Agency (USEPA), the World Health Organization (WHO), and the Iran Standard (IS) permissible limit set for drinking water. In terms of non-carcinogenic, values of toxic elements for children and adult in traditional and industrial fruit juices were 1.6E-3 and 1.72E-3 and 2.6E-3 and 1.85E-3, respectively. The 95th percentile of CR in adults and children due to both industrial and traditional fruits juices was higher than 1E-6; hence, reducing the concentration of As in fruit juices should be conducted. Consumption of fruit juice can increase carcinogenic risk of consumers. Therefore, it is recommended to consume it with caution.

Potentially toxic elements (PTEs) in coastal sediments of Bandar Abbas city, North of Persian Gulf: An ecological risk assessment.

The concentration of potentially toxic elements (PTEs; Lead (Pb), Nickel (Ni), and Cadmium (Cd) Pb, Ni, and Cd), using flame atomic absorption spectrometry (FAAS) was measured in fifty surface coastal sediment samples collected from 5 points coastal sediment of Bandar Abbas city, Iran besides the potential ecological risk index (RI) estimated the environmental health risk. The rank order of PTEs was Pb (52.090 ± 4.113 mg/kg dry weight) > Ni (34.940 ± 8.344 mg/kg dry weight) > Cd (2.944 ± 0.013 mg/kg dry weight). RI due to PTEs in sediments for A, B, C, D, and E points were 187.655, 190.542, 191.079, 189.496, and 192.053, respectively. RI for sampling points A to E was at moderate risk (150 ≤ RI < 300). Therefore, it is recommended to carry out control programs to reduce the amount of PTEs in the coastal sediment of the Persian Gulf.

Steroid hormones in surface water resources in China: systematic review and meta-analysis and probabilistic ecological risk assessment.

A Search was conducted in international databases including Scopus, PubMed, Embase, and Web of Science from 10 January 2005 to 15 January 2023. The risk quotient (RQ) of Estrone (E1), 17ß-E2 (E2), and Estriol (E3) on the surface water resources of China was calculated by Monte Carlo Simulation (MCS) technique. The rank order of steroid hormones based on pooled (weighted average) concentration in surface water was E3 (2.15 ng/l) > E2 (2.01 ng/l) > E1 (1.385 ng/l). The concentration of E1 in Dianchi lake (236.50.00 ng/l), 17ß-E2 in Licun river (78.50 ng/l), and E3 in Dianchi lake (103.1 ng/l) were higher than in other surface water resources in China. RQ related to E1, 17ß-E2 and E3 in 68.00%, 88.89% and 3.92% of surface water resources were high ecological risk, respectively. Therefore, carrying out source control plans for steroid hormones in surface water sources should be conducted continuously.

Evaluation of antibiotic residues in honey: a systematic review and meta-analysis.

Nowadays, incorrect apply of antibiotics to treat infections in honey has led to health risks for humans and antibiotic resistance. Current systematic review and meta-analysis conducted to study antibiotic residues in honey. Data were obtained through searching the databases, including Scopus, Web of Science, PubMed, and other internal databases. The pooled concentration of antibiotic residues was 5.032 (µg/kg) that ranged from 4.72 to 5.33 (µg/kg). The ranking of antibiotics concentration was found in order of fluoroquinolone (8.59 µg/kg) > tetracycline (5.68 µg/kg) > sulfonamides (5.54 µg/kg) > macrolides (4.19µg/kg), respectively. Liquid chromatography-mass spectrometry (LC-MS) method (37.9.7%), high-performance liquid chromatography (HPLC) method (34.4%), and enzyme-linked immunosorbent assay (ELISA) method (27.5.8%) were the most used methods in various studies. In order to avoid contamination, proper use of antibiotics, placement of hives at a suitable distance from agricultural environment, and regular control of antibiotic residues in honey seems to be necessary.

Concentration and non-dietary human health risk assessment of pesticide residues in soil of farms in Golestan province, Iran.

Detection of pesticide residues in soil samples was conducted using UHPLC-MS/MS. Non-dietary health risk assessment was conducted using calculate chronic daily intake (CDI) from ingestion, inhalation and dermal contact pathways and following non-carcinogenic and carcinogenic risks in the adults and adolescent. The rank order of pesticide in soil based on their concentration was malathion (0.082 mg kg-1)> cyproconazole (0.019 mg kg-1)> propargite (0.018 mg kg-1)> butachlor (0.016 mg kg-1) > chlorpyrifos (0.0067 mg kg-1)> diazinon (0.0014 mg kg-1)> imidacloprid (0.0007 mg kg-1). Hazard index (HI) values obtained of exposure to pesticides in soil in adults and adolescent were 0.0012 and 0.0035, respectively. Hence, exposed population are at the acceptable range of non-carcinogenic risk (HI < 1). Cancer risk (CR) values due to propargite in soil via ingestion pathway in adults and adolescent were 2.03E-09 and 2.08E-09, respectively; therefore, carcinogenic risk due to the exposure to pesticide contaminated soil was safe range (CR < 1E-06).

Fluoride in Raw Rice (Oryza sativa): a Global Systematic Review and Probabilistic Health Risk Assessment.

Rice (Oryza sativa) is one of the essential staple foods highly consumed globally, with nearly 40% to 45% of the global population estimated to consume rice. Therefore, consumable rice should have low levels of harmful elements. This study investigates fluoride (F¯) content in raw rice (uncooked rice) and evaluates Probabilistic Health Risk Assessment (PHRA) through Monte Carlo simulation (MCS) due to the consumption of F¯ enriched rice. The literature review reveals that limited studies have been conducted on the investigation of F¯ in raw rice. The fluoride (F¯) concentration in raw rice varies across the studied countries, indicating the need for additional studies to facilitate a more accurate comparison. The F¯ content in raw rice varied among the studied countries, making it difficult to definitively state that the concentration of F¯ in one country is higher. However, the concentration of F¯ in raw rice in India is notably elevated. This study also highlighted the importance of investigating the F¯ content in raw rice. The study will be highly helpful for policymakers to formulate guidelines for water used for irrigation.

Concentration of steroid hormones in sediment of surface water resources in China: systematic review and meta-analysis with ecological risk assessment.

The risk quotient (RQ) related to Estrone (E1), 17ß-E2 (E2), Estriol (E3) and 17α-ethynylestradiol (EE2) in sediment of water resources in China was calculated using Monte Carlo Simulation (MCS) method. Fifty-four papers with 64 data-reports included in our study. The rank order of steroid hormones in sediment based on log-normal distribution in MCS was E1 (3.75 ng/g dw) > E3 (1.53 ng/g dw) > EE2 (1.38 ng/g dw) > E2 (1.17 ng/g dw). According to results, concentration of steroid hormones including E1, E2 and E3 in sediment of Erhai lake, northern Taihu lake and Dianchi river was higher than other locations. The rank order of steroid hormones based on percentage high risk (RQ > 1) was EE2 (87.00%) > E1 (70.00%) > E2 (62.99%) > E3 (11.11%). Hence, contamination control plans for steroid hormones in sediment of water resources in China should be conducted continuously.

Concentration ciguatoxins in fillet of fish: A global systematic review and meta-analysis.

In the current study, an attempt was made to meta-analyze and discuss the concentration of ciguatoxins (CTXs) in fillets of fish based on country and water resources subgroups. The search was conducted in Scopus and PubMed, Embase and Web of Science to retrieve papers about the concentration of CTXs in fillet fish until July 2022. Meta-analysis concentration of CTXs was conducted based on countries and water resources subgroups in the random effects model (REM). The sort of countries based on the pooled concentration of CTXs was Kiribati (3.904 µg/kg) > Vietnam (1.880 µg/kg) > Macaronesia (1.400 µg/kg) > French (1.261 µg/kg) > China (0.674 µg/kg) > Japan (0.572 µg/kg) > USA (0.463 µg/kg) > Spain (0.224 µg/kg) > UK (0.170 µg/kg) > Fiji (0.162 µg/kg) > Mexico (0.150 µg/kg) > Australia (0.138 µg/kg) > Portugal (0.011 µg/kg). CTXs concentrations in all countries are higher than the safe limits of CTX1C (0.1 µg/kg). However, based on the safe limits of CTX1P, the concentrations of CTXs in just Portugal meet the regulation level (0.01 µg/kg). The minimum and maximum concentrations of CTXs were as observed in Selvagens Islands (0.011 µg/kg) and St Barthelemy (7.875 µg/kg) respectively. CTXs concentrations in all water resources are higher than safe limits of CTX1C (0.1 µg/kg) and CTX1B (0.01 µg/kg). Therefore, it is recommended to carry out continuous control pans of CTXs concentration in fish in different countries and water sources.

Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review.

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is being encountered more frequently. PURPOSE: In this study, by compiling the evidence from available meta-analyses, an umbrella systematic review was performed of the neonatal risk factors associated with ADHD. METHODS: The PubMed, Scopus, and Web of Science databases were searched for eligible studies. Only systematic reviews were included. Using a random-effects model, 95% prediction intervals were reported for each risk factor. Three studies were ultimately included in the review. RESULTS: Congenital heart disease, short-duration or incomplete breastfeeding, low birth weight, and 5-minute Apgar scores <7 were significant risk factors for ADHD. However, the quality of the included systematic reviews was low to moderate and the evidence credibility level was suggestive to weak. CONCLUSION: The results of this umbrella review proposed that congenital anomalies, short-duration or incomplete breastfeeding, low birth weight, and low Apgar scores were important factors for the manifestation of ADHD symptoms. However, the inclusion of more high-quality studies is needed to validate our results.

Relationship between Occupational Exposure to Respirable Crystalline Silica and Serum Copper Level as an Indicator of Silicosis: A Systematic Review and Meta-analysis.

Background: This systematic review and meta-analysis study evaluates a relationship between occupational exposure to respirable crystalline silica and serum copper (Cu) levels as an indicator for early detection of silicosis. Materials and Methods: A systematic search was conducted, and the quality of results was evaluated in accordance with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The following databases were searched, including Web of Sciences, Scopus, and PubMed from inception until November 2021. The following keywords were selected for searching in the mentioned databases including, "copper" OR "serum copper" AND "silicosis". The mean (standard deviation [SD]) of Cu was extracted for both silicosis and non-silicosis subjects. The differences in mean effect size were pooled using the random-effect model. Heterogeneity and publication bias were evaluated using the I2 value and Begg's test and Egger's test, respectively. Results: A total of 159 studies were initially found, among which eight studies were included in the meta-analysis. Random-effect meta-analysis of these eight studies showed that silicosis patients had higher copper levels than the non-silicosis group with a pooled standardized mean difference (SMD) of 3.02 (95% confidence interval: 0.25, 5.78); I2 = 99.3%, P value < 0.001. The subgroup analysis showed that the corresponding figures in those with mean age >40 years and <40 years were 5.79 (2.06, 9.52) and -0.43 (-4.57, 3.70), respectively. Moreover, no publication bias was found in the analyses. Conclusions: The results of the present study demonstrated that silica exposure may be associated with increasing serum Cu levels.

The concentration of Lithium in water resources: A systematic review, meta-analysis and health risk assessment.

The presence of trace elements such as lithium (Li) in water resources in the long term can endanger consumers' health. Several studies have been conducted on Li concentration in water sources; hence, this study attempted to retrieve studies using a systematic search. The search was conducted in Web of Sciences, Embase, PubMed, and Scopus databases from 1 January 2010 to 15 January 2023. Li concentration was meta-analyzed based on the type of water resources and countries subgroups in the random effects model (REM) statistical analysis. In addition, health risk assessment in different age groups was calculated using the target hazard quotient (THQ). This study included 76 papers with 157 data reports in our meta-analysis. The overall pooled concentration of Li was 5.374 (95 % CI: 5.261-5.487 µg/L). The pooled concentration of Li in groundwater (40.407 µg/L) was 14.53 times surface water (2.785 µg/L). The highest water Li content was attributed to Mexico (2,209.05 µg/L), Bolivia (1,444.05 µg/L), Iraq (1,350 µg/L), and Argentina (516.39 µg/L). At the same time, the lowest water Li content was associated with Morocco (1.20 µg/L), Spain (0.46 µg/L), and India (0.13 µg/L). THQ due to Li in water resources in consumers of Iraq, Mexico, South Africa, Afghanistan, Bolivia, Portugal, Malawi, South Korea, Nepal, South Korea, Argentina, and the USA was higher than 1 value. Therefore, continuous monitoring of Li concentration in water sources and reducing Li concentration, especially in groundwater water, using new water treatment processes in these countries are recommended.

Content of potentially toxic elements (PTEs) in coffee and coffee-based products: a meta-analysis study, Systematic review, and health risk assessment.

Coffee is the most popular beverage after water in the world, which has an important role in health as a result of various minerals and vitamins but it may be pollution source of potentially toxic elements (PTEs) that can threate the health. Thus, the current study intended to detect the level of PTEs such as Cadmium (Cd), Copper (Cu), Lead (Pb), Nickel (Ni), Znc (Zn) and Iron (Fe), in various coffee and coffee-based products (powder, ground, processed, infusion and bean). Considering the databases of Scopus, Google scholar, PubMed, and Web of Science, the concentration of PTEs in coffee and coffee-based products was retrieved and meta-analyzed. Additionally, the non-carcinogenic risks in terms of total hazard quotient (TTHQ) were assessed using Monte Carlo simulated (MCS) model. According to the findings of 23 articles, the ranking of metal concentration in different coffees was Fe > Zn > Cu> Ni > Pb > Cd in powder, Fe > Cu > Zn> Ni in ground, Fe > Zn > Ni> Cu> Pb > Cd in processed and infusion and Fe > Zn > Ni> Cs > Pb in bean. Moreover, based on WHO regions, the highest concentrations of Cd and Pb (0.742 mg/kg) were related to the South-East Asia Region (SEARO) and European region (EURO) respectively. However, the highest concentrations of Fe (81.161 mg/kg), Zn (33.392 mg/kg), Cu (9.408 mg/kg), and Ni (18.064 mg/kg) were related to Pan American health organization (PAHO), PAHO, PAHO and Eastern Mediterranean Region (EMRO), respectively. On the other hand, the risk pattern was different in different countries. Moreover, consumers in some countries were not at significant non-carcinogenic risks because of ingestion of PTEs via coffee and consumption of coffee-based products.

Potential toxic elements in costal sediment of the Persian Gulf: a systematic review-meta-analysis, non-dietary risk assessment and ecological risk assessment.

Potential toxic element (PTE) contamination in the Persian Gulf has become an important health concern in recent decades. This investigation aimed to meta-analyses of potential toxic elements including lead (Pb), inorganic arsenic (As), cadmium (Cd), nickel (Ni), and mercury (Hg) in the coastal sediment of the Persian Gulf. In this study, an attempt was made to retrieve papers conducted on the concentration of PTE in the coastal sediment of the Persian Gulf by searching in international databases including Web of Science, Scopus, Embase, and PubMed. Meta-analysis concentration of PTE in the coastal sediment of the Persian Gulf was conducted using random effects model based on the country subgroup. Additionally, non-dietary risk assessment including non-carcinogenic and carcinogenic risks from ingestion, inhalation and dermal contact routes and ecological risk assessment was estimated. Seventy-eight papers with 81 data-reports (1650 sample size) were included in our meta-analysis. The rank order of heavy metals in coastal sediment of the Persian Gulf based on pooled concentration was Ni (65.44 mg/kg) > Pb (58.35 mg/kg) > As (23.78 mg/kg) > Cd (1.75 mg/kg) > Hg (0.77 mg/kg). The highest concentration of As, Cd, Pb, Ni, and Hg was observed in the coastal sediment of Saudi Arabia, Arab Emirates, Qatar, Iran, and Saudi Arabia, respectively. Although the Igeo index in coastal sediment of the Persian Gulf was in grade 1 (uncontaminated) and grade 2 (slightly contaminated) but total target hazard quotient (TTHQ) of adults and adolescent was higher than 1 value in Iran, Saudi Arabic, United Arab Emirates, and Qatar. Total cancer risk (TCR) for adults and adolescent due to As was higher than 1E-6 in Iran, United Arab Emirates, and Qatar but TCR for adolescents due to As was higher than 1E-6 in Saudi Arabic. Therefore, it is recommended to monitor the concentration of PTE and implementation of programs to reduce the emission of PTE from resources in the Persian Gulf.

The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat.

Background: Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease. Method: In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days. Results: Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-α (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica. Conclusion: These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure.

The Level of Heavy Metal in Fresh and Processed Fruits: A Study Meta-analysis, Systematic Review, and Health Risk Assessment.

Intake of fruits is important for health. However, it can be a contamination source of potentially toxic elements (PTEs). The present study aimed to investigate the concentration of PTEs such as arsenic (As), lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), and Iron (Fe) in various fresh and processed fruits. All the studies related to the concentration of PTEs in fresh and processed fruits by international databases including were included and non-carcinogenic risks assessment was evaluated based on the total hazard quotient (TTHQ). According to findings highest concentrations of As, Cd and Pb were observed in pineapple, mango, and cherry, while the lowest concentrations of these metals were found in berries, pineapple, and berries. Regarding trace elements, peach and cucumber represented the highest and lowest concentrations of Fe, respectively. Moreover, the highest and lowest concentrations of Cu were related to plum and banana, respectively. Considering the type of continents, the highest concentrations of As, Cd, Pb, Fe, Ni, and Cu among fresh and processed fruits belonged to Pan American Health Organization (EMRO), EMRO, African Region (AFRO), European Region (EURO), AFRO, and Western Pacific Region (SEARO). Eventually, the non-carcinogenic risk assessment of the heavy metal in fresh and processed fruits indicated that the risk pattern was different in various countries and the calculated TTHQ level in infants was below 1. Overall, the consumption of fresh and processed fruits is safe and does not pose a risk to the health of consumers.