ABSTRACT
BACKGROUND: We observed evidence of protein-losing nephropathy in some dogs with coccidioidomycosis, suggestive of immune complex glomerulonephritis (ICGN). The goal of this study was to understand the prevalence of renal histopathologic lesions and proteinuria in dogs with coccidioidomycosis. HYPOTHESIS: Biochemical and histopathological evidence of glomerular lesions is present in dogs with coccidioidomycosis. ANIMALS: Hundred and fifty-six dogs with naturally occurring coccidioidomycosis. METHODS: Retrospective case series. Clinical information and results of clinicopathologic testing were retrieved from the University of California, Davis Veterinary Medical Teaching Hospital (VMTH). Microscopic sections of renal tissue procured from necropsy of dogs with coccidioidomycosis were examined to evaluate the nature and distribution of lesions. RESULTS: A total of 156 dogs with coccidioidomycosis were identified; 87 dogs had serum biochemistry and a urinalysis performed, 17 had urine protein:creatinine ratios (UPCs), and 24 had renal tissue available for histopathology. Eleven (13%) of the 87 dogs were azotemic, 55 (63%) were proteinuric (of which 14 [25%] had clinically relevant proteinuria defined as ≥3+ or ≥500 mg/dL), and 14 dogs had UPC ≥0.5 (range, 0.5-21.5, median 4.2). Thirteen (54%) of 24 dogs had renal histopathologic lesions suggestive of ICGN. Seven of these dogs had urinalyses performed; 5 (71%) had clinically relevant proteinuria as described above. Two dogs (33%) with normal glomeruli had granulomatous nephritis, 1 of which had intralesional Coccidioides spherules. CONCLUSIONS AND CLINICAL IMPORTANCE: Coccidioidomycosis should be considered as a possible contributor to glomerular disease in dogs. Whether similar lesions occur in other mammalian hosts, including humans, warrants further investigation.
Subject(s)
Coccidioidomycosis/veterinary , Dog Diseases/etiology , Kidney Diseases/veterinary , Animals , Coccidioidomycosis/etiology , Coccidioidomycosis/pathology , Dog Diseases/pathology , Dogs , Female , Kidney Diseases/etiology , Kidney Diseases/pathology , Male , Retrospective StudiesABSTRACT
A report is given on the development of the subsidies granted by the "Niedersächsische Tierseuchenkasse" für BVD/MD since 1973. The article shows the cyclic procedure and regional differences as well as the participation of vaccinations and embryo transfer at the frequent occurrence of persistent viraemic animals in single herds. According to the authors' opinion the struggle against BVD/MD must have two aims: 1. to search for and to cull out persistent viraemic animals 2. to prevent the arise of new persistent viraemic animals.
Subject(s)
Bovine Virus Diarrhea-Mucosal Disease/prevention & control , Communicable Disease Control/economics , Viremia/veterinary , Animals , Cattle , Germany , Viremia/prevention & controlABSTRACT
A summary is given of general and specific aspects and jurisdiction in connection with sections 66-71 (compensation for damages of the German animal epidemic law). The author can be contacted for specific details.
Subject(s)
Animals, Domestic , Disease Outbreaks/veterinary , Legislation, Veterinary , Animals , Disease Outbreaks/legislation & jurisprudence , GermanyABSTRACT
An evaluation of data from the "Niedersächsische Tierseuchenkasse" with reference to various forms of cattle husbandry shows the crucial influence quality of farm management resp. age structure of the stock are having upon the frequency of animal diseases at least as far as the salmonellosis of cattle is concerned. The assessment takes into account the earlier repeatedly identified relationship between occurrence of animal diseases and stock size. The obligations of the "Niedersächsische Tierseuchenkasse" per contributory animal due to losses in fattening calves farms are about three times as high as in "conventional" cattle farms keeping stock of all ages. The "Niedersächsische Tierseuchenkasse" has therefore developed a special premium class for this specific type of farming with a generally higher premium level. Further measures aiming to improve the current situation of cattle salmonellosis are being discussed.
