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Biol Chem ; 398(9): 995-1007, 2017 08 28.
Article in English | MEDLINE | ID: mdl-28095368

ABSTRACT

Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients.


Subject(s)
Iron Overload/complications , Iron/metabolism , Ovarian Neoplasms/complications , Ovarian Neoplasms/metabolism , Animals , Bacteria/metabolism , Female , Humans , Ovarian Neoplasms/microbiology , Oxidative Stress
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