ABSTRACT
Melanogenesis is a biosynthetic pathway to produce melanin pigment in melanocyte, involving a series of intricate enzymatic and chemical catalyzed reactions. Melanogenesis involves five signaling pathways that converge on microphthalmia-associated transcription factor. In addition, many cytokines, involved in the regulation of melanogenesis, play an important role in the development, proliferation, differentiation and migration of melanocytes. Polyoxometalate can be used as a potential inhibitor of melanin production. Hence, this paper reviews the signaling pathways of melanogenesis and their regulatory mechanism, to apply polyoxometalates in the melanin production pathway, and briefly introduces the regulatory factors of related pathways.
Subject(s)
Cell Differentiation , Melanins , Melanocytes , Microphthalmia-Associated Transcription Factor , Signal TransductionABSTRACT
From the perspective of philosophy,centering on the background,the realistic problems and the fu-ture trend of medicine,this paper analyzed the nature-understanding of medicine and the meaning of integration,and put forward that integration meantto reshape the view of life,health,and knowledge.
