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1.
Microbiol Spectr ; : e0040124, 2024 Jun 25.
Article in English | MEDLINE | ID: mdl-38916348

ABSTRACT

The aim of the present study was first to isolate Helicobacter pylori from gastric biopsy specimens and to test their antibiotic susceptibility. Second, it was to evaluate the efficacy of the standard triple therapy from patients of the west central region of Colombia. H. pylori positive patients received standard triple therapy with proton pump inhibitor (PPI) (40 mg b.i.d.), clarithromycin (500 mg b.i.d.), and amoxicillin (1 g b.i.d.) for 14 days. Thereafter, antibiotic susceptibility of the isolates was assessed by E-Test. From 94 patients enrolled, 67 were positive for H. pylori by histology or culture. Overall resistance to metronidazole, levofloxacin, rifampicin, clarithromycin, and amoxicillin was 81%, 26.2%, 23.9%, 19%, and 9.5%, respectively. No resistance was found for tetracycline. A total of 54 patients received standard triple therapy, 48 attended follow-ups testing, and of them, 30 had resistance test reports. Overall eradication rate was 81.2%. Second-line treatment was given to eight patients, four of whom were followed up with a 13C urea breath test (UBT) and remained positive for H. pylori. Eradication was significantly higher in patients with clarithromycin susceptible than in resistant strains (95.6% vs 42.8% P = 0.001). The updated percentages of resistance to clarithromycin in this geographical area had increased, so this value must be considered when choosing the treatment regimen.IMPORTANCEAntibiotic resistance in Helicobacter pylori has increased worldwide, as has resistance to multiple antimicrobials (MDRs), which seriously hampers the successful eradication of the infection. The ideal success rate in eradicating H. pylori infection (≥90%) was not achieved in this study (81.2%). This is the first time that MDR is reported (14.3%) in the region; the resistance to clarithromycin increased over time (3.8%-19%), and levofloxacin (26.2%) and rifampicin (23%) resistant isolates were detected for the first time. With these results, strain susceptibility testing is increasingly important, and the selection of treatment regimen should be based on local antibiotic resistance patterns.

2.
Cult. cuid. enferm ; 17(1): 45-62, 2020.
Article in Spanish | LILACS, COLNAL, BDENF - Nursing | ID: biblio-1247565

ABSTRACT

Objetivo: Determinar las conductas del cuidador que afectan el proceso de crianza de los niños en etapas preescolar y escolar basado en la revisión bibliográfica. Metodología: Esta revisión bibliográfica integrativa fue realizada a través de un estudio detallado, selectivo y crítico que sintetiza la información en una perspectiva unitaria y de conjunto; para mostrar resultados de investigaciones anteriores, y recoger las conclusio-nes de la literatura sobre las conductas del cuidador que afectan el proceso de crianza de los niños en etapas preescolar y escolar.Resultados: Las conductas más relevantes encontradas en la literatura, que afectan el proceso de crianza de los niños son: el lenguaje inapropiado que usan los cuidadores ha-cia ellos, la violencia, los malos tratos, la carencia de afecto y apoyo hacia ellos. Además de estas conductas hay un factor comportamental de rol por carencia de tiempo de los padres para compartir con los hijos, esta variable de la falta de tiempo para dedicar a sus hijos, ha generado cuidadores indirectos y cambios en la conducta de los niños por mala utilización del tiempo en ellos. Conclusiones: Esta revisión crítica de la literatura evidencio que conductas simples y cotidianas para algunas personas como el lenguaje inapropiado, la violencia, el tiempo o carencia de este, el poco afecto en el hogar afectan negativamente el proceso de crianza de los niños, y generan daños irremediables en los niños; modificando su estado de ánimo, su manera de ser, su estilo de vida, su salud y su comportamiento a largo plazo ya que serán adolescentes y adultos con dificultades sociales, e incapaces de enfrentar un mundo con adversidades diarias.


Subject(s)
Behavior , Health , Caregivers
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