Subject(s)
Cystadenocarcinoma/diagnosis , Cystadenocarcinoma/surgery , Cystadenoma/diagnosis , Cystadenoma/surgery , Gallbladder Neoplasms/diagnosis , Gallbladder Neoplasms/surgery , Adult , Cystadenocarcinoma/pathology , Cystadenoma/pathology , Diagnosis, Differential , Female , Gallbladder Neoplasms/pathology , Humans , Tomography, X-Ray ComputedSubject(s)
Lipomatosis , Thyroid Diseases , Female , Humans , Lipomatosis/pathology , Male , Middle Aged , Thyroid Diseases/pathologySubject(s)
Adenocarcinoma, Follicular/pathology , Mixed Tumor, Malignant/pathology , Thyroid Neoplasms/pathology , Adenocarcinoma, Follicular/complications , Adenocarcinoma, Follicular/diagnosis , Adenocarcinoma, Follicular/diagnostic imaging , Biopsy, Fine-Needle , Carcinoma, Neuroendocrine , Diagnosis, Differential , Female , Humans , Middle Aged , Mixed Tumor, Malignant/diagnosis , Mixed Tumor, Malignant/diagnostic imaging , Thyroid Neoplasms/complications , Thyroid Neoplasms/diagnosis , Thyroid Neoplasms/diagnostic imaging , UltrasonographySubject(s)
Gastrointestinal Neoplasms/diagnosis , Gastrointestinal Stromal Tumors/diagnosis , Jejunal Neoplasms/diagnosis , Neoplasms, Vascular Tissue/diagnosis , Acute Disease , Adult , Diagnosis, Differential , Gastrointestinal Neoplasms/complications , Gastrointestinal Neoplasms/pathology , Gastrointestinal Neoplasms/surgery , Gastrointestinal Stromal Tumors/complications , Gastrointestinal Stromal Tumors/pathology , Gastrointestinal Stromal Tumors/surgery , Humans , Jejunal Neoplasms/complications , Jejunal Neoplasms/pathology , Jejunal Neoplasms/surgery , Male , Neoplasms, Vascular Tissue/complications , Neoplasms, Vascular Tissue/pathology , Neoplasms, Vascular Tissue/surgery , Peritonitis/diagnosis , Peritonitis/etiology , Peritonitis/surgerySubject(s)
Mixed Tumor, Malignant/pathology , Pancreatic Neoplasms/pathology , Humans , Male , Middle AgedABSTRACT
BACKGROUND: Orbital hydatidosis is rare, accounting for only 1% of all hydatid cysts. Herein we report a case and review the sparse literature. METHODS: Case report and review of pertinent literature. RESULTS: A 74-year-old farmer presented with progressive proptosis and loss of vision of the left eye. Evaluation revealed a hydatid cyst of the orbit. Orbital hydatidosis is usually unilateral and unaccompanied by cysts elsewhere in the body. Most affected are children and young adults. Although there is no gender predominance, orbital hydatidosis may affect the left eye preferentially. Onset is usually insidious over several months. Serologic testing is unreliable, and imaging by computed tomography or magnetic resonance imaging is now standard. Surgical resection is curative, but albendazole must be administered postoperatively if there is spillage intraoperatively. CONCLUSIONS: Hydatid cysts should be included in the differential diagnosis of unilateral proptosis in patients from regions where echinococcosis is endemic.
Subject(s)
Echinococcosis/diagnosis , Eye Infections, Parasitic/diagnosis , Aged , Agriculture , Albendazole/administration & dosage , Anthelmintics/administration & dosage , Echinococcosis/drug therapy , Echinococcosis/pathology , Echinococcosis/surgery , Eye Infections, Parasitic/drug therapy , Eye Infections, Parasitic/pathology , Eye Infections, Parasitic/surgery , Head/diagnostic imaging , Humans , Male , Tomography, X-Ray ComputedSubject(s)
Adenocarcinoma/diagnosis , Epithelial Cells/pathology , Fallopian Tube Diseases/diagnosis , Fallopian Tubes/pathology , Adult , Curettage , Diagnosis, Differential , Fallopian Tube Diseases/surgery , Fallopian Tube Neoplasms/diagnosis , Fallopian Tubes/surgery , Female , Humans , Hyperplasia/diagnosis , Hyperplasia/surgeryABSTRACT
OBJECTIVE: To analyze epidemiological characteristics, clinical symptoms, radiological aspects, treatment and outcome of central nervous system hydatidosis and compare our results with those reported in literature. PATIENTS AND METHODS: In our retrospective study, we reviewed 39 cases of primary central nervous system hydatid cysts operated on in our hospital between 1998 and 2007. RESULTS: There were 20 male and 19 female patients (sex-ratio M/F=1.05) between 2 and 68 years of age (mean=26.5 years). Thirteen of the patients were children (33.3%) with a mean age of 6.8 years and 26 were adults (66.7%) with a mean age of 36.3 years. The location of hydatid cysts was intracranial in 27 cases (69.2%) and spinal in 12 cases (30.8%). Headache and motor deficits were the predominant symptoms in patients with intracranial hydatidosis whereas back pain and spinal cord compression syndrome were the most frequent clinical presentations in patients with spinal hydatidosis. All patients underwent surgical resection of the cyst. Pathologic findings were consistent with hydatid cyst in all cases. During the follow-up period which ranged between 12 months and 5 years, 12 patients had recurrence (30.7%). Only one patient with intracranial hydatid cyst died postoperatively due to anaphylactic shock. CONCLUSION: Despite all the advances in imaging techniques and therapeutic methods, central nervous system hydatidosis remains difficult to cure and patient outcomes are not satisfactory especially in case of spinal involvement due to the high incidence of recurrence.
Subject(s)
Central Nervous System Helminthiasis/pathology , Echinococcosis/pathology , Adolescent , Adult , Aged , Brain/diagnostic imaging , Brain/pathology , Central Nervous System Helminthiasis/diagnostic imaging , Central Nervous System Helminthiasis/therapy , Child , Child, Preschool , Echinococcosis/diagnostic imaging , Echinococcosis/therapy , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neuroendoscopy , Neurosurgical Procedures , Postoperative Complications/epidemiology , Recurrence , Retrospective Studies , Spinal Cord/diagnostic imaging , Spinal Cord/pathology , Tomography, X-Ray Computed , Tunisia , Young AdultABSTRACT
Only 0.5 to 2% of hydatid cysts are localized in the skeleton and of these, 3 to 4% are found in the skull. In this paper, the authors report a case of primary hydatidosis involving the cranial vault revealed by a bulging mass of the forehead and symptoms of raised intracranial pressure that occurred in a 22-year-old woman who came from a rural area. Through this case and literature review, the authors analyse the epidemiological, clinical and radiological aspects of skull hydatidosis. They conclude that hydatid cyst should be considered in the differential diagnosis of any soft tissue swelling or osteolytic lesion in the scalp of patients living in endemic areas.
Subject(s)
Echinococcosis/diagnosis , Frontal Bone/parasitology , Albendazole/therapeutic use , Animals , Antiprotozoal Agents/therapeutic use , Craniotomy , Diagnosis, Differential , Echinococcosis/physiopathology , Echinococcosis/therapy , Echinococcus granulosus , Female , Frontal Bone/diagnostic imaging , Frontal Bone/pathology , Headache , Humans , Radiography , Treatment Outcome , Vomiting , Young Adult , Zoonoses/epidemiology , Zoonoses/parasitologyABSTRACT
AIMS: The aims of our study were to determine the frequency of granulomatous hepatitis in patients with peritoneal tuberculosis, to identify factors for high risk and whether it is associated with higher frequency of antituberculous treatment side effects. METHODS: We carried out a prospective study on patients with histologically proven peritoneal tuberculosis between January 1996 and December 2005. We performed a liver biopsy in all the patients before starting the antituberculous treatment. Granulomatous hepatitis was systematically searched in all patients. RESULTS: The study was conducted in 52 patients, 9 men and 43 women of median age of 35,5 years. A granulomatous hepatitis was seen in 24 patients (46%). In univariate analysis the factors associated with a high risk of liver involvement were a higher level of gamma-glutamyl transpeptidase (44.5 + 36.8 IU/l vs 23.3 + 9.28 IU/l p = 0.005), a higher level of phosphatases alkalines (233.9 + 96.6 IU/l vs 189.4 + 49.9 IU/l p = 0.03) and a lower level of cholesterol (1.22 + 0.2 g/l vs 156 + 0.3 g/l p < 0.0001). In multivariate analysis, only a cholesterol level lower than 1,31 g/l was significantly associated with a granulomatous hepatitis (p = 0.006 OR [IC 95%]: 0.10 [0.02-052]). CONCLUSION: We have found a frequent liver involvement in the case of peritoneal tuberculosis (46%). Cholesterol level lower than 1,31 gr/l was an independent predictor of granulomatous hepatitis in patients with peritoneal tuberculosis. We suggest, in this case, that percutaneous liver biopsy can be considered as an alternative to laparoscopy.
Subject(s)
Granuloma/etiology , Hepatitis/etiology , Peritonitis, Tuberculous/complications , Adult , Female , Granuloma/epidemiology , Hepatitis/epidemiology , Humans , Liver Diseases/epidemiology , Liver Diseases/etiology , Male , Prognosis , Prospective Studies , Risk FactorsABSTRACT
AIMS: Solitary fibrous tumours (SFT) of the central nervous system are rare neoplasms that usually present as dura-based masses and clinically resemble meningiomas. Histologically, they can be similar to haemangiopericytoma or fibrous meningioma. We present herewith a pathological study of eight patients with SFT and compare our results with the published data. METHODS: All tumours diagnosed as SFT over a period of 15 years were retrieved from the files of La Rabta Hospital Department of Pathology, Tunisia. Routine histological sections were prepared from formalin-fixed, paraffin-embedded specimens. Immunohistochemical analysis was performed using antibodies raised against vimentin, CD34, CD99, Bcl-2 and MIB-1. RESULTS: The SFT group consisted of four males and four females with a mean age of 44 years. The tumours were supratentorial in six cases, tentorial in one case and located in the lateral right ventricle in the last case. All patients underwent surgery as initial treatment. Histologically, SFT were similar to their soft tissue counterparts. Two cases demonstrated increased cellularity, marked nuclear hyperchromasia and marked cellular pleomorphism. Only the later two cases recurred after 6 months of follow-up. CONCLUSION: Little is known about the biological behaviour of SFT, although most seem amenable to total resection.
Subject(s)
Brain Neoplasms/pathology , Solitary Fibrous Tumors/pathology , Adult , Biomarkers, Tumor/analysis , Brain Neoplasms/chemistry , Brain Neoplasms/surgery , Diagnosis, Differential , Disease-Free Survival , Dura Mater/pathology , Female , Hemangiopericytoma/diagnosis , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Male , Meningioma/diagnosis , Middle Aged , Radiosurgery , Solitary Fibrous Tumors/chemistry , Solitary Fibrous Tumors/surgeryABSTRACT
BACKGROUND: Hydatidosis is a parasitic endemic disease in Tunisia. The liver and lung are the most common sites of involvement; however, it can develop anywhere in the body. AIM: The aim of the present study was to analyse the epidemiological features of extrapulmonary hydatid cysts and compare our results with those reported in literature. METHODS: A retrospective study of 265 extrapulmonary hydatid cysts collected over the 18-year period from 1990 to 2007 was undertaken. RESULTS: There were 101 male and 164 female patients (sex ratio M/F = 0.61) ranging in age from 2 to 84 years (mean age = 38.7). In our series, hydatid cysts involved mainly the kidney (24.1%), the central nervous system (22.6%), the liver (19.6%) and the spleen (11.3%). The other less frequent sites included the peritoneum (n = 9), heart (n = 9), bone (n = 6), adrenal gland (n = 4), epiploon (n = 4), orbit (n = 4), ovary (n = 3), prostate (n = 2), bladder (n = 2), breast (n = 2), Douglas' cul-de-sac (n = 2), diaphragm (n = 1), testis (n = 1), broad ligament (n = 1), mediastinum (n = 1), nasal cavity (n = 1), soft tissue (n = 1), abdominal wall (n = 1), parotid gland (n = 1), psoas muscle (n = 1), synovia (n = 1), thymus (n = 1) et le pancreas (n = 1). CONCLUSION: In contrast to literature, our results show that hydatid cysts of the kidney and of the central nervous system are more frequent than hepatic location which occupies the 3rd rank.
Subject(s)
Echinococcosis/epidemiology , Echinococcosis/parasitology , Adolescent , Adult , Aged , Aged, 80 and over , Central Nervous System Parasitic Infections/epidemiology , Child , Child, Preschool , Digestive System Diseases/epidemiology , Digestive System Diseases/parasitology , Echinococcosis/pathology , Endocrine System Diseases/epidemiology , Endocrine System Diseases/parasitology , Female , Female Urogenital Diseases/epidemiology , Female Urogenital Diseases/parasitology , Heart Diseases/epidemiology , Heart Diseases/parasitology , Humans , Incidence , Male , Male Urogenital Diseases/epidemiology , Male Urogenital Diseases/parasitology , Mediastinal Diseases/epidemiology , Mediastinal Diseases/parasitology , Middle Aged , Musculoskeletal Diseases/epidemiology , Musculoskeletal Diseases/parasitology , Retrospective Studies , Tunisia/epidemiologyABSTRACT
BACKGROUND: Intracranial germ cell tumors are rarely seen and typically localize in the pineal or suprasellar region. The largest category of germ cell tumors is dysgerminoma. AIM: to describe clinicopathological features and immunohistochemical profile of dysgerminomas. CASE REPORT: We report three cases of central nervous system dysgerminomas. There were two young women and a man who were 6, 11 and 23-year-old. They presented with symptoms of insipidus diabetes (n=3) with association to visual field defects in the third case. Radiological findings showed a supra seller lesion in two cases. Double localization in the pineal and suprasellar regions was seen in the third case. Histologic examination and immunohistochemical study of surgical specimen were consistent with primary central nervous system dysgerminoma.