[Pituitary apoplexy in giant cell adenoma].

Hemorrhage in giant cell adenomas of the pituitary gland was detected in 20.8%. It occurred mostly in supracellular mixed multi-nodular tumors. The course of the disease was symptom-free, acute, subacute or mild. There was a relationship between pituitary apoplexy course, on the one hand, and age and tumor growth, on the other. Since postoperative complication and lethality rates were relatively higher in younger patients, it is suggested that differentiated approach be taken to the diagnosis and management of the disease.

[The stimulating effect of prolactin on the neurite growth of sensory neurons in an organotypic culture]. / Stimuliruiushchee vliianie prolaktina na rost neiritov chuvstvitel'nykh neironov v organotipicheskoi kul'ture.

Prolactine was found to promote neurite extension in chick embryo dorsal root ganglia in vitro. This hormone was active at the concentration 10-50 ng/ml provided extensive neurite outgrowth in the bioassay, compared to the control. The liquor from patients with prolactinoma was also found to promote neurite extension. This fact may be used for prolactinoma diagnostics.

[The evaluation and choice of treatment methods (surgical removal, proton-beam irradiation) in endosellar hypophyseal adenomas]. / Otsenka i vybor metodov lecheniia (khirurgicheskoe udalenie, obluchenie puchkom protonov) éndoselliarnykh adenom gipofiza.

The article analyses the immediate and late-term results of treatment of endosellar pituitary adenomas: removal through a transsphenoidal approach--16 patients, transnasal stereotaxic administration of 90Y--14 patients, irradiation by proton beam--263 patients. Surgery as well as radiotherapy produced quite satisfactory results. Proton therapy on a Leningrad synchrocyclotron is not inferior to the modern surgical methods in efficacy and safety. It is indicated in endosellar pituitary adenomas when the sella turcica measures no more than 20 x 16 mm.

[Bioelectrical activity of the brain after proton therapy of hypophyseal adenoma]. / Bioélektricheskaia aktivnost' golovnogo mozga posle protonnoi terapii adenomy gipofiza.

In 37 patients with endosellar pituitary adenoma attended by the acromegaloid syndrome, a plasma STH level determined by a radioimmunoassay against a background of an insulin test was compared with EEG findings before and at varying time (up to 7 yrs.) after proton beam therapy using the synchrocyclotron of the Leningrad Institute of Nuclear Physics. EEG was shown to be an informative method of diagnosis of continuous pituitary adenoma growth and complications of proton beam therapy in the form of temporal paroxysms.

[Metabolic pool of free amino acids in the blood and cerebrospinal fluid of patients with pituitary adenoma before and after proton therapy]. / Metabolicheskii fond svobodnykh aminokislot krovi i spinnomozgovoi zhidkosti u bol'nykh adenomoi gipofiza do i posle protonnoi terapii.

A pool of free amino acids was studied in blood and cerebrospinal fluid of 34 patients with adenoma of hypophysis before proton therapy and within 3 years after the treatment. The course of proton therapy was shown to cause a regression of the disease, a decrease in content of somatotropic hormone in blood as well as to normalize the metabolic pool of amino acids in blood and cerebrospinal fluid.

[Neurologic and electroencephalographic evaluations after a single irradiation of pituitary adenomas with protons having 1000 MeV of energy]. / Nevrologicheskie i élektroéntsefalograficheskie otsenki pri odnokratnom obluchenii adenom gipofiza protonami s énergiei 1000 MeV.

The brain was examined (on the basis of neurological and electroencephalographic findings) in 43 patients with hypophysis adenomas both before and at various intervals after a single exposure of the tumour to protons with an energy of 1,000 MeV. The irradiation was performed by the stereotaxic convergent method. The radiation dose absorbed by the tumour was 100 Gy. The local character of the proton action, absence of irreversible changes in the brain, temporary, transient changes on the part of the oculomotor nerves (25.5%) and temporal lobes (9.3%) are demonstrated. The objective remission of the disease was attained in 97.7% of the cases.