[Cardio-ankle vascular index (CAVI) in diagnostics, risk and severity evaluation of magistral vessels lesion in patients with cardio-vascular diseases and type 2 diabetes].

Assesment of arterial stiffness the substantional prognostic factor for evaluating complications of cardiovascular diseases (CVD) in patients with atherosclerosis, hypertension and type 2 diabetes, may be performed using different parameters, including cardio-ankle vascular index (CAVI). The main purpose of this review is to analyze data from studies where CAVI is used to test the arterial wall stiffness in magistral vessels. CAVI measurement is non-invasive and performed by portable devices which makes it comfortable for ambulatory use in patients who come for a check-up and also in those who already are hospitalized. It does not require any special knowledge from investigator and the test lasts a couple of minutes long. CAVI does not depend on blood pressure changes and is more specific in structural changes of arterial wall assessment than brachial-ankle pulse wave velocity (baPWV). CAVI shows considerable correlation with markers of CVD like atherosclerotic plaques in vessels, diastolic disfunction of left ventricle and angina pectoris. CAVI may be used for early monitoring and assessing the lesions of target organs in patients with atherosclerosis, chronic hypertension and type 2 diabetes. Establishing CAVI as a standart parameter in assessing patients who are at risk of CVD can help to improve complications prevention, reduce mortality and prolong their lifespan.

[Early diagnosis of Takayasu's disease (clinical case report)].

Nonspecific aortoarteritis (Takayasu s disease, obliterating aortoarteritis, disease of the missing pulse) is a systemic inflammatory disease of aorta and its branches, which leads to stenosis and ischemia of surrounding tissues. This disease is more common in young women and characterized by slowly progressive course with significant impairing quality of life. Etiology of the Takayasu's disease is unknown. Syndrome of the systemic inflammatory reaction with the clinical manifestations of the effects of lesions of the aorta and its branches at different anatomical levels (symptom: coarctation, abdominal ischemia, coronary, renovascular hypertension, lesions of the pulmonary artery) are criteria of this systematic process. Angiography can detect typical vascular changes due to a nonspecific aortoarteritis and remains the gold standard for its verification. The effectiveness of conservative therapy, surgical treatment, the prognosis for life is entirely determined by the detection of this insidious disease in the initial stages of its development. Until today, the early detection of non-specific aortoarteriite is not generally accepted and widely used, and therefore remain relevant.

[Prophylaxis of ischemic heart lesions during chronic heart failure with complex therapy using Q10 coenzyme].

Dysfunction of energy processes in the myocardium, resulting the background of ischemic syndrome, and inadequate intake of energy substrates process and/or breach of energetic cofactors of oxidation are an important pathogenetic aspects of the progression of myocardial dysfunction and congestive heart failure. Level of Q10 Coenzyme plays a key role in the functioning of the respiratory mitochondrial chains, exerting a significant influence on the synthesis of ATP. The article provides data on the use of Q10 coenzyme in the treatment of 76 patients with circulatory failure. The data obtained points on the improvement of myocardial contractility, increased exercise tolerance, reduced content of the final products of lipid peroxidation in plasma, a positive effect on blood lipid profile with the addition of Qudesan to standard therapy of heart failure.