[Biochemical changes in rats under the influence of cesium chloride].

Cesium is lately accumulated actively in the environment, but its influence on human and animal organism is the least studied among heavy metals. It is shown that the action of cesium chloride in rats caused significant changes in blood chemistry, which are characterized by a decrease of total protein content, pH, an increase in the level of urea, creatinine, glucose and total hemoglobin. The results showed that potassium content in all the studied organs and tissues of poisoned rats decreases under the action of cesium chloride. Histological examination of the heart tissue in rats poisoned with cesium chloride indicates the onset of pathology of cardiovascular system. It was found out that use of the drug "Asparkam" reduces the negative effect of cesium chloride on the body of rats.

[Comparison of blood biochemical indices in rats exposed to lead in macrodispersed form and nanoform].

It is shown that the increasing content of lead in blood (6.3 and 3.7 times) and liver (30.1 and 4.6 times) in rats after 14-days per os exposure both to lead acetate (macrodispersed form) and lead nanoparticles (nanoform) in a dose of 7 mg/100 g of body weight leads to the increased of activity of blood enzymes: alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase and a decrease of creatinine level. Lead in nanoform with slight accumulation, due to the greater elimination, expressed higher biological activity and reactivity as compared to macrodispersed form. Thus the exposure to lead in different dispersed form suggests metabolic disorders in rats, and accumulation of lead and biochemical changes are more expressed in the liver.

[Age characteristics of cadmium content in the organism of poisoned rats with experimental metabolic acidosis].

The paper demonstrates age peculiarities of cadmium content in the liver, kidneys and spleen of 3-month and 18-month rats poisoned by cadmium sulfate. It was registered that the content of cadmium is 266.7 times higher in 3-month old rats, and 141.8 times in 18 months rats in comparison with intact ones. A biological model of introducing 3-month and 18-month rats into the state of metabolic acidosis before and after poisoning with cadmium sulfate was developed. The result of the research showed that changes in acid-base equilibrium of poisoned rats towards metabolic acidosis may influence a decrease of cadmium content in their organisms. Thus, when modeling of metabolic acidosis before the poisoning with cadmium, the content of cadmium decreases in 3-month rats' liver by 21%, in kidneys by 53%; in metabolic acidosis modeling after cadmium poisoning its content decreases, accordingly, by 44% and by 56.5% in comparison with the just poisoned ones. In metabolic experimental acidosis modeling the content of cadmium in 3-month poisoned rats' spleen decreased by 36.5% before and after poisoning. Such changes were also registered in 18-month old rats but to lower extent. Thus, the results of the researches showed more effective correction of cadmium intoxication decrease in the organism of 3-month rats when using the model of acid-base equilibrium change in the organisms of poisoned animals.

[Effect of cadmium sulphate on the metabolism of carbohydrates in organism of rats of different ages].

The influence of cadmium sulfate on concentration of glucose, lactate, piruvate, alpha-ketoglutarate, malate, oxaloacetate in blood of 3-, 6- and 18-month-old poisoned rats was established the results of our researches. It was found, that poisoning of rats by cadmium sulfate causes the rise of concentration of glucose, metabolites of citric acid cycle and glycolysis in blood of animals of all age groups explored. The research results prove that in blood of 3-month-old poisoned rats the level of glycolysis and citric acid cycle activation is considerably higher in comparison with that of 6- and 18-month-old animals. As a result, a comparison of age-specific dynamics of changes of carbohydrate metabolism indices in the blood of rats, poisoned by cadmium showed that the organism of 3-month-old rats is more sensitive to toxic influence of cadmium.

[Age-dependent cadmium accumulation in organs of intoxicated rats and changes of indices of acid-base balance of blood in different conditions of antioxidant defence]. / Vikovi osoblyvosti kumuliatsiï kadmiiu v orhanakh toksykovanykh shchuriv i zminy pokaznykiv kyslotno-luzhnoho stanu krovi za riznykh umov antyoksydantnoho zakhystu orhanizmu.

Age peculiarities of cadmium cumulation in the organs of rats under different conditions of antioxidants administration. Considerable hepato- and nefrotoxic effect of the given xenobiotic under different conditions of its supply into the organism was revealed. The strongly pronounced differences between the age distribution of cadmium in the organisms have been marked. It is proved that the most antioxidantal activity is shown by sodium selenite when administered into the organism before poisoning with cadmium. It is stated that the indices showing the acid-alkaline state are subject to the greatest changes in the bodies of young animals. In this case they have more expressed toxic effects under the influence of ions of heavy metals as well as the receptivity to the positive influence of antioxidants.

[Theoretical and practical aspects of vitaminology in development of animal husbandry in Ukraine]. / Teoretychni ta praktychni aspekty vitaminologii u rozvytku tvarynnytstva v Ukraïni.

The paper deals with fundamental and applied aspects ofvitaminology development in Ukraine. Its foundations have been laid by A. V. Palladin and R. V. Chagovets, leading scientists of the country, and continued by their followers. Joint efforts of scientists in the field of veterinary, medicine, food branch will permit creating new up-to-date technologies for production of vitamin drugs of a new generation with the corresponding financial support of the state. That is rather necessary for health of the future generation of people.

[Biochemical characterization of noduleless soybean lectins]. / Biokhimichni osoblyvosti lektyniv bezbul'bochkovoï soï.

The comparative analysis of activity and hydrocarbon specificity of lectins from common soybean and soybean in which roots the nodules do not form has been carried out. It was shown that the root lectins possesses the less activity in comparison with the seed lectins. The both kinds of lectins most specifically link with mannitol. The supposition was made about the role of activity and hydrocarbon specificity of lectins from soybean in the establishment of symbiotic systems of nitrogen fixation.