Subject(s)
Biocompatible Materials/pharmacology , Durapatite/pharmacology , Estrone/pharmacology , Wound Healing/drug effects , Wounds and Injuries/drug therapy , Administration, Topical , Animals , Autoradiography , Bone Regeneration/drug effects , Cell Division/drug effects , Disease Models, Animal , Drug Therapy, Combination , Male , Rats , Rats, Wistar , Tooth Extraction , Wounds and Injuries/pathologyABSTRACT
Experiments on white rats revealed that introduction of Ossocol, a sponge with a composition of hydroxyl apatite with collagen, into a removed tooth well prevented mandibular atrophy and was conducive to a more smooth defect filling with better compact bone tissue. Ossocol use in 214 patients with bone tissue defects developing after tooth removal, of odontogenic cysts, sequestra, and after radical surgery for periodontal diseases demonstrated a positive effect of this agent on the course of the postoperative period: the defect was more rapidly replaced by bone tissue. No unfavorable local or general reactions to Ossocol implantation were observed.
Subject(s)
Bone Substitutes/therapeutic use , Collagen/therapeutic use , Durapatite/therapeutic use , Adolescent , Adult , Animals , Bone Regeneration/drug effects , Bone Substitutes/pharmacology , Collagen/pharmacology , Contraindications , Drug Combinations , Drug Evaluation , Drug Evaluation, Preclinical , Durapatite/pharmacology , Female , Humans , Male , Mandible/pathology , Mandible/surgery , Middle Aged , Rats , Rats, Wistar , Time Factors , Tooth Extraction/methodsABSTRACT
Synthetic hydroxylapatite, a drug made in this country, enhanced reparative osteogenesis if introduced in the dental well of a white rat. The regenerate represented solid bone structure in 4 months after tooth removal.
Subject(s)
Alveolar Process/drug effects , Hydroxyapatites/therapeutic use , Wound Healing/drug effects , Animals , Bone Regeneration/drug effects , Drug Evaluation, Preclinical , Durapatite , Male , Mandible , Rats , Rats, Wistar , Time Factors , Tooth ExtractionABSTRACT
The method suggested by the authors permits a reliable reproduction of mandibular osteomyelitis in white rats. The primary localization and pattern of the infectious process in this model well correspond to odontogenic osteomyelitis, this permitting a preclinical study of new drugs and physiotherapeutic methods intended for patients with odontogenic diseases.
Subject(s)
Disease Models, Animal , Mandibular Diseases/etiology , Osteomyelitis/etiology , Animals , Focal Infection, Dental/diagnostic imaging , Focal Infection, Dental/etiology , Incisor/surgery , Mandible/diagnostic imaging , Mandibular Diseases/diagnostic imaging , Osteomyelitis/diagnostic imaging , Radiography , Rats , Staphylococcal Infections/diagnostic imaging , Staphylococcal Infections/etiology , Time Factors , Tooth Extraction , Tooth ReplantationABSTRACT
In 19 rabbits, lower branches of facial nerve were experimentally sectioned and sutured to its middle branches to form a 'side to end' pattern with 2 to 3 epineural sutures. Morphological investigation showed that regenerating axons of the middle branch penetrate into the sutured trunk and grow further. The technique was applied in 7 patients. Full functional recovery was evidenced in 4 of them. The technique is recommended for clinical routine.
