ABSTRACT
Las neumonía eosinofílica se clasifica por su presentación en aguda o crónica; las características distintivas se basan en la presencia de tos, disnea, fiebre e infiltrados pulmonares con acumulación de células inflamatorias, predominante de eosinófilos. La asociación de eosinofilia y padecimientos reumatológicos es bien conocida, como en el caso de la fascitis eosinofílica y el síndrome de Churg-Strauss. La coexistencia de neumonía eosinofílica crónica y artritis reumatoide ha sido reportada, ya sea de inicio coincidente o en artritis reumatoide establecida. El papel fisiopatológico de los eosinófilos en las enfermedades autoinmunes no está bien definido, sin embargo se ha demostrado que la producción de citocinas proinflamatorias estimulan y activan diferentes grupos celulares, pudiendo en forma simultánea inducir autoanticuerpos e incremento y/o infiltración de eosinófilos en diversos tejidos, sin tener una enfermedad autoinmune subyacente. Presentamos el caso de una mujer joven con neumonía eosinofílica crónica con manifestaciones clínicas reumatológicas y presencia de autoanticuerpos, que se resolvió en forma espontánea (AU)
Eosinophilic pneumonia is classified by its acute or chronic presentation, the distinguishing characteristics of which are based on the presence of cough, dyspnea, fever and pulmonary infiltrates with accumulation of inflammatory cells, predominantly eosinophils. The association of eosinophilia and rheumatologic disorders is well known, as in the case of eosinophilic fasciitis and the Churg-Strauss syndrome. The coexistence of chronic eosinophilic pneumonia and rheumatoid arthritis has been reported, either early rheumatoid arthritis of definitive disease. The pathophysiological role of eosinophils in autoimmune diseases is not well defined, however it has been shown that the production of pro-inflammatory cytokines stimulate and activates different cell groups, and can simultaneously induce autoantibodies and/or increased infiltration of eosinophils in various tissues, without an underlying autoimmune disease. The case of a young woman with rheumatic chronic eosinophilic pneumonia manifestations and the presence of autoantibodies, which resolved spontaneously, is presented here (AU)
Subject(s)
Humans , Female , Middle Aged , Pulmonary Eosinophilia/complications , Pulmonary Eosinophilia/diagnosis , Pulmonary Eosinophilia/immunology , Immune System Diseases/complications , Immune System Diseases/diagnosis , Arthritis, Rheumatoid/complications , Churg-Strauss Syndrome/complications , Churg-Strauss Syndrome/diagnosis , Diagnosis, Differential , Glucocorticoids/therapeutic use , Pulmonary Eosinophilia/drug therapy , Cough/complications , Cough/diagnosis , Dyspnea/complications , Fever/complications , Fever/etiology , Churg-Strauss Syndrome/physiopathology , Radiography, Thoracic/methods , Radiography, Thoracic/trendsABSTRACT
Eosinophilic pneumonia is classified by its acute or chronic presentation, the distinguishing characteristics of which are based on the presence of cough, dyspnea, fever and pulmonary infiltrates with accumulation of inflammatory cells, predominantly eosinophils. The association of eosinophilia and rheumatologic disorders is well known, as in the case of eosinophilic fasciitis and the Churg-Strauss syndrome. The coexistence of chronic eosinophilic pneumonia and rheumatoid arthritis has been reported, either early rheumatoid arthritis of definitive disease. The pathophysiological role of eosinophils in autoimmune diseases is not well defined, however it has been shown that the production of pro-inflammatory cytokines stimulate and activates different cell groups, and can simultaneously induce autoantibodies and/or increased infiltration of eosinophils in various tissues, without an underlying autoimmune disease. The case of a young woman with rheumatic chronic eosinophilic pneumonia manifestations and the presence of autoantibodies, which resolved spontaneously, is presented here.
