Histomorphometric analysis of early epithelialization and dermal changes in mid-partial-thickness burn wounds in humans treated with porcine small intestinal submucosa and silver-containing hydrofiber.

The objective of this study was to determine the healing rates of mid-partial-thickness burns treated with a porcine intestinal submucosa (SIS) vs. silver-containing cellulose hydrofiber (AgH) dressings. This was done by comparing healing response of burn wounds treated with SIS vs that of burns treated with AgH dressings. Five patients with mid-partial-thickness burns ≤10% of body surface were treated simultaneously, but in different areas, with SIS and AgH dressings; full-thickness biopsies were taken at days 0 and 7. Tissues treated with SIS presented higher epithelial maturation index (6.2 ± 0.84 vs. 3.2 ± 3.28; [mean ± standard deviation], P = .029), better orientation and differentiation of epithelial cells, as well as an appropriate basal lamina structure, collagen deposition, and higher transforming growth factor-ß3 expression (7.4 ± 8.1 vs. 2.1 ± 2.6; P = .055) than tissues treated with AgH dressings. Importantly, after the treatment SIS was not integrated in healed tissues. After 3 months of treatment, SIS produced a lower score according to Vancouver Scar Scale (3.6 ± 2.6 vs. 7.2 ± 2.5, P = .025).The submucosa dressing does not simply act as scaffolding for the wound, it provides stimulation in the healing area, probably via growth factors initially present in SIS or matrikines derived from its digestion in the wound site. In conclusion, the present study demonstrated that biological matrices favor the wound-healing process.

[Critical points for success in supracricoid partial laryngectomy with cricohyoidepiglottoepexy]. / Puntos críticos en el éxito de la laringectomía parcial supracricoidea (LPS) con cricohioidoepiglotopexia (CHEP).

Cancer of the larynx is a relatively rare neoplasia in Mexico as well as in the rest of the world; however, evolution of treatment in recent years showed important results in terms of survival and local control. Supracricoid partial laryngectomy with cricohyoidoepiglottopexy is a surgical technique that permits similar oncologic results to other conservatives techniques for glottic carcinoma, with excellent functional results. The objective of the present work was to show the critical points of the technique based on the description of Laccourreye, emphasizing the anatomical aspect of resection and reconstruction to avoid complications and achieve best results.