ABSTRACT
Although the diagnostic criteria for Kawasaki disease (KD) have been clearly defined, there are many reports on other signs associated with the disease. Kabani et al. in 1991 described three consecutive patients with combined atypical presentation of the disease and communicating hydrocele. To our knowledge, the first case of hydrocele during the course of KD was that described by us in 1990. Here we present an additional case of hydrocele developed at the onset of a typical Kawasaki disease. We think that hydrocele must be reported in the list of possible signs associated with Kawasaki disease and that if present, it should be particularly usefull for diagnosis of atypical presentation of the disease.
Subject(s)
Mucocutaneous Lymph Node Syndrome/diagnosis , Testicular Hydrocele/diagnosis , Diagnosis, Differential , Humans , Infant , Male , Mucocutaneous Lymph Node Syndrome/complications , Testicular Hydrocele/etiologyABSTRACT
Desferrioxamine (DFO), an iron-chelating drug, up to today has been essential for the care of thalassaemic patients. Unfortunately it presents some toxic effects. One of these is sensorineural hypoacusia, already reported some years ago. In 1987 we documented in our patients a prevalence of 19.4% (7 cases of 36) of sensorineural hypoacusia that proved to be significantly associated with the highest pro kg/die doses of DFO. We made a follow-up audiometry over a 5-year period after a general adjustment of the DFO dosage related to serum Ferritin levels. Four patients with mild hypoacusia (30-50 dB) showed normal audiometry after one year. The hypoacusia of the two severe cases (50-80 dB) proved stable until 5-years later in one case and increased in the other. Only a new case arose denovo. In pathologic patients "Therapeutic index" (DFO/serum Ferritin) was significantly higher than in normoacusic ones and the "threshold" value between the two populations was of 0.027. We think that the Therapeutic index may be a useful guideline to calculate safe doses of DFO about ototoxicity.
Subject(s)
Deferoxamine/adverse effects , Hearing Loss, Sensorineural/etiology , beta-Thalassemia/drug therapy , Adolescent , Adult , Audiometry , Deferoxamine/administration & dosage , Deferoxamine/therapeutic use , Dose-Response Relationship, Drug , Female , Follow-Up Studies , Hearing Loss, Sensorineural/diagnosis , Humans , Male , Retrospective Studies , Severity of Illness Index , beta-Thalassemia/epidemiologyABSTRACT
There is no general agreement about the possibility that pancreatitis could be regarded as a clinical complication of Salmonella infection. We report 2 cases of salmonellosis WHO were admitted to our Department for clinical and biological signs of pancreatitis. Our observation agrees with other reported cases, suggesting that patients affected by salmonellosis with upper abdominal pain should be investigated for concomitant pancreatitis; on the other hand in patients suffering from diarrhea with hyperamylasaemia, salmonellosis should be considered as a likely explanation for their clinical condition.
Subject(s)
Pancreatitis/etiology , Salmonella Infections/complications , Child , Female , Humans , Pancreatitis/diagnosis , Pancreatitis/microbiology , Salmonella/isolation & purification , Salmonella Infections/microbiologyABSTRACT
The Melkersson-Rosenthal syndrome is a rare disease of unknown pathogenesis. Classical signs include recurrent facial palsy, lingua plicata and orofacial edema. The diagnosis is often difficult when all features are not present at the same time: in the literature complete triads occurred in 25-30% of the patients. We report a case of Melkersson-Rosenthal syndrome with classical triad of signs in a 13 year old boy. The pathology, clinical features and management of this disease are discussed: the possible role of food allergy or additives intolerance is also examined.
